Excitatory interaction between glutamate receptors and protein kinases

T. R. Soderling; S. E. Tan; E. McGlade‐McCulloh; H. Yamamoto; K. Fukunaga

doi:10.1002/neu.480250310

Excitatory interaction between glutamate receptors and protein kinases

T. R. Soderling, S. E. Tan, E. McGlade‐McCulloh, H. Yamamoto, K. Fukunaga

Vollum Institute

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

One of the most active areas of neurobiology research concerns mechanisms involved in paradigms of synaptic plasticity. A popular model for cellular leaning and memory is long term potentiation (LTP) in hippocamus. LTP requires postsynaptic influx of Ca²⁺ which triggers multiple biochemical pathways resulting in pre‐ and postsynaptic mechanisms enhancing long term synaptic efficiency. This article focuses on an acute postsynaptic Mechanism that can enhance responsiveness of glutamate receptors. Evidence is presented that calcium/calmodulin/dependent protein kinase II, the major potsynaptic density protein at excitatory glutaminergic synapses, can phosphorylate glutamate receptors and enhance ion current flowing through them. 1994 John Wiley & Sons, Inc.

Original language	English (US)
Pages (from-to)	304-311
Number of pages	8
Journal	Journal of Neurobiology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1002/neu.480250310
State	Published - Mar 1994

Keywords

glutamate receptors
protein kinases
synaptic plasticity

ASJC Scopus subject areas

General Neuroscience
Cellular and Molecular Neuroscience

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AU - Yamamoto, H.

AU - Fukunaga, K.

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Excitatory interaction between glutamate receptors and protein kinases

Abstract

Keywords

ASJC Scopus subject areas

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