Recently, it was recognized that an immune response develops along one of two major pathways. One leads to a destructive immune response (type 1), while the alternative leads to a nondestructive immune response (type 2). Our studies in animal models suggest that therapeutic vaccines induce a tumor-specific type 1 immune response while ineffective vaccines induce a type 2 response. These results have led us to examine the immune response in sentinel lymph nodes draining tumor vaccines of patients entered onto clinical trials for melanoma, breast and renal cell cancer.
- Immune deviation
- Immunological monitoring
- Sentinel lymph nodes
- Tumor vaccine-draining lymph nodes
- Tumor vaccines
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging