Evolutionary History and Genetic Variation of Macaca mulatta and Macaca fascicularis

Betsy Ferguson, David Glenn Smith

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Scopus citations

    Abstract

    The geographic distributions of rhesus and cynomolgus macaques exceed those of all other nonhuman primate (NHP) species and encompass regional populations that are genetically distinct. Indian and Chinese rhesus macaques represent the two most divergent regional populations of rhesus macaques, whereas the Indochinese cynomolgus macaque reflects an introgression of Chinese rhesus macaque genes. Genome variant discovery studies have not only informed the evolutionary history of macaques, but also have provided insight into the range of potential functional alleles and diversity among populations. The challenge ahead is to more fully characterize the natural variation within and between macaque species, both to maximize the utility of macaques as models of human disease, as well as to inform their use in the development and testing of pharmacogenetic drug therapies.

    Original languageEnglish (US)
    Title of host publicationThe Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
    PublisherElsevier Inc.
    Pages17-35
    Number of pages19
    ISBN (Electronic)9780124171466
    ISBN (Print)9780124171442
    DOIs
    StatePublished - Mar 12 2015

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    Keywords

    • Disease model
    • Drug safety
    • Evolution
    • Genome
    • Macaque
    • Polymorphism

    ASJC Scopus subject areas

    • Medicine(all)
    • Pharmacology, Toxicology and Pharmaceutics(all)

    Cite this

    Ferguson, B., & Smith, D. G. (2015). Evolutionary History and Genetic Variation of Macaca mulatta and Macaca fascicularis. In The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment (pp. 17-35). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-417144-2.00002-0