Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution

Lucia Carbone, R. Alan Harris, Gery M. Vessere, Alan R. Mootnick, Sean Humphray, Jane Rogers, Sung K. Kim, Jeffrey D. Wall, David Martin, Jerzy Jurka, Aleksandar Milosavljevic, Pieter J. De Jong

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Gibbon species have accumulated an unusually high number of chromosomal changes since diverging from the common hominoid ancestor 15-18 million years ago. The cause of this increased rate of chromosomal rearrangements is not known, nor is it known if genome architecture has a role. To address this question, we analyzed sequences spanning 57 breaks of synteny between northern white-cheeked gibbons (Nomascus l. leucogenys) and humans. We find that the breakpoint regions are enriched in segmental duplications and repeats, with Alu elements being the most abundant. Alus located near the gibbon breakpoints (

Original languageEnglish (US)
Article numbere1000538
JournalPLoS Genetics
Volume5
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Hylobates
Hylobatidae
cytosine
Cytosine
karyotype
methylation
common ancestry
Karyotype
karyotyping
Methylation
genome
Genomic Segmental Duplications
Alu Elements
Hominidae
Synteny
ancestry
Genome
rate

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)

Cite this

Carbone, L., Harris, R. A., Vessere, G. M., Mootnick, A. R., Humphray, S., Rogers, J., ... De Jong, P. J. (2009). Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution. PLoS Genetics, 5(6), [e1000538]. https://doi.org/10.1371/journal.pgen.1000538

Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution. / Carbone, Lucia; Harris, R. Alan; Vessere, Gery M.; Mootnick, Alan R.; Humphray, Sean; Rogers, Jane; Kim, Sung K.; Wall, Jeffrey D.; Martin, David; Jurka, Jerzy; Milosavljevic, Aleksandar; De Jong, Pieter J.

In: PLoS Genetics, Vol. 5, No. 6, e1000538, 06.2009.

Research output: Contribution to journalArticle

Carbone, L, Harris, RA, Vessere, GM, Mootnick, AR, Humphray, S, Rogers, J, Kim, SK, Wall, JD, Martin, D, Jurka, J, Milosavljevic, A & De Jong, PJ 2009, 'Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution', PLoS Genetics, vol. 5, no. 6, e1000538. https://doi.org/10.1371/journal.pgen.1000538
Carbone, Lucia ; Harris, R. Alan ; Vessere, Gery M. ; Mootnick, Alan R. ; Humphray, Sean ; Rogers, Jane ; Kim, Sung K. ; Wall, Jeffrey D. ; Martin, David ; Jurka, Jerzy ; Milosavljevic, Aleksandar ; De Jong, Pieter J. / Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution. In: PLoS Genetics. 2009 ; Vol. 5, No. 6.
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