Evidence that a humoral immune response to autologous cartilage proteoglycan can participate in the induction of cartilage pathology

Thomas F. Kresina, Jung U. Yoo, Victor M. Goldberg

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We examined antiproteoglycan antibodies as an autoimmune response for induction of synovitis. This hypothesis was studied by monitoring humoral antiproteoglycan antibody following IgG induction of experimental immune synovitis, localization in the articular cartilage of an autologous immune response, and loss of proteoglycan from cartilage following intravenous administration of antiproteoglycan monoclonal antibodies. The data support the hypothesis that autoimmunity to cartilage macromolecules may play a role in the etiopathogenesis of arthritis.

Original languageEnglish (US)
Pages (from-to)248-257
Number of pages10
JournalArthritis & Rheumatism
Volume31
Issue number2
DOIs
StatePublished - Feb 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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