Evidence supporting the memory disruption hypothesis of electro-convulsive shock action

Gary Banker, Earl Hunt, Robert Pagano

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Electroconvulsive shock (ECS) following training is known to disrupt performance on passive avoidance tasks. The effect is usually seen as evidence that ECS produces retrograde amnesia. Recently it was reported that if passive avoidance training was followed by a second footshock (FS) several hours after training, and then ECS, impaired avoidance was shown on subsequent testing. This was interpreted as showing that the training-ECS interval is not crucial, thus questioning the retrograde amnesia hypothesis. Our repetition of the double foot-shock studies, however, failed to replicate these observations. We did notice that the second FS made animals hyperactive, suggesting that this is not an appropriate procedure in passive avoidance studies. We then used a double foot-shock paradigm in a situation involving both passive avoidance and discriminated avoidance. The experimental animals moved more rapidly, but displayed no amnesia in their choice behavior. Amnesia was observed when ECS followed seconds after training. The results are in accord with the retrograde amnesia hypothesis.

Original languageEnglish (US)
Pages (from-to)895-899
Number of pages5
JournalPhysiology and Behavior
Volume4
Issue number6
DOIs
StatePublished - Nov 1969

Keywords

  • Discrimination learning
  • Electro-convulsive shock
  • Memory
  • Passive avoidance
  • Rat

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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