Evidence for two differentially regulated populations of peripheral β-endorphin-releasing cells in humans

M. Michele Murburg, Charles W. Wilkinson, Murray A. Raskind, Richard C. Veith, Daniel Dorsa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In the current study we tested the hypothesis that human plasma β-endorphin (βE) is derived from at least two subpopulations of βE-releasing cells: one sensitive to glucocorticoids as well as to dopamine (DA; regulated analogously to the corticotrophs of the rat pituitary), and one insensitive to glucocorticoids but sensitive to DA (regulated analogously to the melanotrophs of the rat pituitary). To test this hypothesis, human plasma levels of ACTH, cortisol, and βE-like immunoreactivity were measured at baseline and after haloperidol treatment (0.05 mg/kg, iv) in two experimental groups, one pretreated with dexamethasone (1.5 mg) and one pretreated with placebo. Plasma PRL levels were also measured in both groups as an indicator of DA receptor blockade. Dexamethasone partially suppressed both baseline and haloperidol-stimulated levels of human plasma βE-like immunoreactivity, whereas it completely suppressed both basal and haloperidol-stimulated levels of ACTH and cortisol and had no statistically significant effect on either basal or haloperidol-stimulated PRL levels. These data support a negative feedback effect of glucocorticoids on one DA-sensitive cell population that releases both ACTH and βE (corticotroph like), but not on a second cell population that releases βE but not ACTH.

Original languageEnglish (US)
Pages (from-to)1033-1040
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume77
Issue number4
StatePublished - Oct 1993
Externally publishedYes

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Endorphins
Haloperidol
Plasma (human)
Adrenocorticotropic Hormone
Corticotrophs
Glucocorticoids
Cells
Dexamethasone
Population
Hydrocortisone
Rats
Melanotrophs
Vulnerable Populations
Dopamine
Placebos
Feedback
Plasmas

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Evidence for two differentially regulated populations of peripheral β-endorphin-releasing cells in humans. / Murburg, M. Michele; Wilkinson, Charles W.; Raskind, Murray A.; Veith, Richard C.; Dorsa, Daniel.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 77, No. 4, 10.1993, p. 1033-1040.

Research output: Contribution to journalArticle

Murburg, M. Michele ; Wilkinson, Charles W. ; Raskind, Murray A. ; Veith, Richard C. ; Dorsa, Daniel. / Evidence for two differentially regulated populations of peripheral β-endorphin-releasing cells in humans. In: Journal of Clinical Endocrinology and Metabolism. 1993 ; Vol. 77, No. 4. pp. 1033-1040.
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