Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3

Pushpa Jayaraman, Tuofu Zhu, Lynda Misher, Deepika Mohan, LaRene Kuller, Patricia Polacino, Barbra A. Richardson, Helle Bielefeldt-Ohmann, David Anderson, Shiu Lok Hu, Nancy Haigwood

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25 Scopus citations

Abstract

To model human immunodeficiency virus (HIV) perinatal transmission, we studied infection of simian-human immunodeficiency virus (SHIV) SF162P3 in 10 pregnant Macaca nemestrina females and their offspring. Four of nine infants born to and suicided by these dams had evidence of infection, a transmission rate of 44.4% (95% confidence interval, 13.7% to 78.8%). We quantified transplacentally acquired and de novo Env-specific immunoglobulin G (IgG), IgM, and neutralizing antibodies in newborns. Transmission of escape variants was confirmed. In utero infection (n = 1) resulted in high viremia, depletion of peripheral CD4+ T cells, and rapid evolution of env in blood and tissues. Peripartum or postpartum SHIV infection (n = 3) resulted in postacute viral control that was undetectable by very sensitive multiplex PCR, despite increasing antibodies. Seropositive infants with highly controlled viremia had homogeneous peripheral blood env sequences, and their tissues had

Original languageEnglish (US)
Pages (from-to)822-834
Number of pages13
JournalJournal of Virology
Volume81
Issue number2
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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