Evidence for linkage and association to alcohol dependence on chromosome 19

Ana M. Valdes, Shannon McWeeney, Glenys Thomson

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

An association study on markers showing suggestive evidence for linkage to severe alcoholism was performed on the Collaborative Study on the Genetics of Alcoholism (COGA) data set. Our linkage study was restricted to the autosomal markers on chromosomes 2, 3, 4, 13, and 19, with low homozygosity (below 30%) and high identity-by-state sharing in affected sib pairs (ASPs). We used a strict phenotype definition, only individuals diagnosed as affected both on the ALDX1 (COGA criterion) and ALDX2 (ICD-10) scales were used in the analyses. Linkage was assessed by excess identity-by-descent allele sharing in ASPs. The strongest evidence of linkage was detected on chromosome 19, in particular at markers D19S49 (p <0.0001) and D19S431 (p <0.002). An association study of allele and haplotype data was then carried out on chromosome 19 markers using affected-family-based controls. A haplotype defined by alleles at markers D19S49, D19S43, and D19S200 in chromosome 19 shows significant association (p <0.003, odds ratio 2.82). Further, significant differences were observed in the distribution of the harm avoidance subscale among genotypes defined by D19S49 (p <0.0001). These results provide evidence for the existence of a locus in chromosome 19 potentially involved in alcohol dependence susceptibility.

Original languageEnglish (US)
JournalGenetic Epidemiology
Volume17
Issue numberSUPPL. 1
StatePublished - 1999
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 19
Alcoholism
Alleles
Haplotypes
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 2
International Classification of Diseases
Genetic Markers
Odds Ratio
Genotype
Phenotype

Keywords

  • Affected family based controls
  • Harm avoidance

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Evidence for linkage and association to alcohol dependence on chromosome 19. / Valdes, Ana M.; McWeeney, Shannon; Thomson, Glenys.

In: Genetic Epidemiology, Vol. 17, No. SUPPL. 1, 1999.

Research output: Contribution to journalArticle

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