Evidence for functional trace amine associated receptor-1 in normal and malignant B cells

Agata M. Wasik; Mark J. Millan; Thomas Scanlan; Nicholas M. Barnes; John Gordon

doi:10.1016/j.leukres.2011.10.002

Evidence for functional trace amine associated receptor-1 in normal and malignant B cells

Agata M. Wasik, Mark J. Millan, Thomas Scanlan, Nicholas M. Barnes, John Gordon

Chemical Physiology and Biochemistry

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Following the observation that dopaminergic componor1 School of Immunity ents are present in normal and malignant B cells, we now provide evidence that they additionally express the functionally related trace amine-associated receptor-1 (TAAR1). Immunodetectable TAAR1 was found in lines derived from a broad range of B-cell malignancy; and in tonsillar B cells, particularly when activated. L3055 Burkitt's lymphoma cells were shown to respond to prototypical TAAR1 agonists in cytotoxicity assays with features of apoptotic death evident; normal B cells were somewhat less sensitive to the agonists. These data raise the possibility that TAAR1 may have therapeutic relevance to leukemia, lymphoma, and wider B-cell pathologies.

Original language	English (US)
Pages (from-to)	245-249
Number of pages	5
Journal	Leukemia Research
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/j.leukres.2011.10.002
State	Published - Feb 2012

Keywords

Apoptosis
B cells
Dopamine
Lymphoma
MDMA
Trace amine

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2011.10.002

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title = "Evidence for functional trace amine associated receptor-1 in normal and malignant B cells",

abstract = "Following the observation that dopaminergic componor1 School of Immunity ents are present in normal and malignant B cells, we now provide evidence that they additionally express the functionally related trace amine-associated receptor-1 (TAAR1). Immunodetectable TAAR1 was found in lines derived from a broad range of B-cell malignancy; and in tonsillar B cells, particularly when activated. L3055 Burkitt's lymphoma cells were shown to respond to prototypical TAAR1 agonists in cytotoxicity assays with features of apoptotic death evident; normal B cells were somewhat less sensitive to the agonists. These data raise the possibility that TAAR1 may have therapeutic relevance to leukemia, lymphoma, and wider B-cell pathologies.",

keywords = "Apoptosis, B cells, Dopamine, Lymphoma, MDMA, Trace amine",

author = "Wasik, {Agata M.} and Millan, {Mark J.} and Thomas Scanlan and Barnes, {Nicholas M.} and John Gordon",

note = "Funding Information: This work was supported in part by funding from Leukaemia and Lymphoma Research (U.K.) and National Institutes of Health grant ( DK-52798 ). J.G. wrote the paper while in receipt of a Raine Visiting Professorship at the University of Western Australia. We thank Clotilde Mannoury la Cour for technical advice and help. ",

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AU - Wasik, Agata M.

AU - Millan, Mark J.

AU - Scanlan, Thomas

AU - Barnes, Nicholas M.

AU - Gordon, John

N1 - Funding Information: This work was supported in part by funding from Leukaemia and Lymphoma Research (U.K.) and National Institutes of Health grant ( DK-52798 ). J.G. wrote the paper while in receipt of a Raine Visiting Professorship at the University of Western Australia. We thank Clotilde Mannoury la Cour for technical advice and help.

PY - 2012/2

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N2 - Following the observation that dopaminergic componor1 School of Immunity ents are present in normal and malignant B cells, we now provide evidence that they additionally express the functionally related trace amine-associated receptor-1 (TAAR1). Immunodetectable TAAR1 was found in lines derived from a broad range of B-cell malignancy; and in tonsillar B cells, particularly when activated. L3055 Burkitt's lymphoma cells were shown to respond to prototypical TAAR1 agonists in cytotoxicity assays with features of apoptotic death evident; normal B cells were somewhat less sensitive to the agonists. These data raise the possibility that TAAR1 may have therapeutic relevance to leukemia, lymphoma, and wider B-cell pathologies.

AB - Following the observation that dopaminergic componor1 School of Immunity ents are present in normal and malignant B cells, we now provide evidence that they additionally express the functionally related trace amine-associated receptor-1 (TAAR1). Immunodetectable TAAR1 was found in lines derived from a broad range of B-cell malignancy; and in tonsillar B cells, particularly when activated. L3055 Burkitt's lymphoma cells were shown to respond to prototypical TAAR1 agonists in cytotoxicity assays with features of apoptotic death evident; normal B cells were somewhat less sensitive to the agonists. These data raise the possibility that TAAR1 may have therapeutic relevance to leukemia, lymphoma, and wider B-cell pathologies.

KW - Apoptosis

KW - B cells

KW - Dopamine

KW - Lymphoma

KW - MDMA

KW - Trace amine

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JO - Leukemia Research

JF - Leukemia Research

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ER -

Evidence for functional trace amine associated receptor-1 in normal and malignant B cells

Abstract

Keywords

ASJC Scopus subject areas

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