Evidence for functional trace amine associated receptor-1 in normal and malignant B cells

Agata M. Wasik, Mark J. Millan, Thomas Scanlan, Nicholas M. Barnes, John Gordon

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Following the observation that dopaminergic componor1 School of Immunity ents are present in normal and malignant B cells, we now provide evidence that they additionally express the functionally related trace amine-associated receptor-1 (TAAR1). Immunodetectable TAAR1 was found in lines derived from a broad range of B-cell malignancy; and in tonsillar B cells, particularly when activated. L3055 Burkitt's lymphoma cells were shown to respond to prototypical TAAR1 agonists in cytotoxicity assays with features of apoptotic death evident; normal B cells were somewhat less sensitive to the agonists. These data raise the possibility that TAAR1 may have therapeutic relevance to leukemia, lymphoma, and wider B-cell pathologies.

Original languageEnglish (US)
Pages (from-to)245-249
Number of pages5
JournalLeukemia Research
Volume36
Issue number2
DOIs
StatePublished - Feb 1 2012

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Keywords

  • Apoptosis
  • B cells
  • Dopamine
  • Lymphoma
  • MDMA
  • Trace amine

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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