Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease

H. Payami, G. D. Schellenberg, S. Zareparsi, J. Kaye, G. J. Sexton, M. A. Head, S. S. Matsuyama, L. F. Jarvik, B. Miller, D. Q. McManus, T. D. Bird, R. Katzman, L. Heston, D. Norman, G. W. Small

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Our earlier studies had suggested a possible association between the HLA-A2 allele and Alzheimer's disease (AD). In the present study we tested the hypothesis that A2 is associated with earlier AD onset. We performed two independent studies: a collaborative study with 111 patients and a confirmatory study with 96 patients. We found similar patterns of reduced age at onset as a function of A2 in both data sets. Overall, A2 was associated with a significant 3-year shift to earlier onset. The effects of A2 and ε4 on age at onset appeared additive. Our results suggest A2, or a closely linked gene, modulates onset age of AD. Association with A2 would suggest an immune/inflammatory response mechanism for AD.

Original languageEnglish (US)
Pages (from-to)512-518
Number of pages7
Issue number2
StatePublished - Aug 1997

ASJC Scopus subject areas

  • Clinical Neurology


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