Evidence for an association between infant mortality and homozygosity for the arctic variant of carnitine palmitoyltransferase 1A

Bradford D. Gessner, Thalia Wood, Monique A. Johnson, Carolyn (Sue) Richards, David Koeller

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose:Infant mortality in Alaska is highest among Alaska Native people from western/northern Alaska, a population with a high prevalence of a genetic variant (c.1436C>T; the arctic variant) of carnitine palmitoyltransferase 1A (CPT1A).Methods:We performed an unmatched case-control study to determine the relationship between the arctic variant and infant mortality. The cases were 110 Alaska Native infant deaths from 2006 to 2010 and the controls were 395 Alaska Native births from the same time period. In addition to the overall analysis, we conducted two subanalyses, one limited to subjects from western/northern Alaska and one limited to infants heterozygous or homozygous for the arctic variant.Results:Among western/northern Alaska residents, 66% of cases and 61% of controls were homozygous (adjusted odds ratio (aOR): 2.5; 95% confidence interval (CI): 1.3, 5.0). Among homozygous or heterozygous infants, 58% of cases and 44% of controls were homozygous (aOR: 2.3; 95% CI: 1.3, 4.0). Deaths associated with infection were more likely to be homozygous (OR: 2.9; 95% CI: 1.0-8.0). Homozygosity was strongly associated with a premorbid history of pneumonia, sepsis, or meningitis.Conclusion:Homozygosity for the arctic variant is associated with increased risk of infant mortality, which may be mediated in part by an increase in infectious disease risk. Further studies are needed to determine whether the association we report represents a causal association between the CPT1A arctic variant and infectious disease-specific mortality.

Original languageEnglish (US)
Pages (from-to)933-939
Number of pages7
JournalGenetics in Medicine
Volume18
Issue number9
DOIs
StatePublished - Sep 1 2016

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Carnitine O-Palmitoyltransferase
Infant Mortality
Confidence Intervals
Communicable Diseases
Odds Ratio
Meningitis
Case-Control Studies
Sepsis
Pneumonia
Parturition
Mortality
Infection
Population
Alaska Natives

Keywords

  • Alaska Native
  • carnitine palmitoyltransferase 1A
  • fatty acid oxidation
  • indigenous populations
  • infant mortality

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics(clinical)

Cite this

Evidence for an association between infant mortality and homozygosity for the arctic variant of carnitine palmitoyltransferase 1A. / Gessner, Bradford D.; Wood, Thalia; Johnson, Monique A.; Richards, Carolyn (Sue); Koeller, David.

In: Genetics in Medicine, Vol. 18, No. 9, 01.09.2016, p. 933-939.

Research output: Contribution to journalArticle

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