Evidence for an adrenal origin of plasma estrogens in alcoholic men

David H. Van Thiel, Donald (Lynn) Loriaux

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Abstract

Alcoholic men have high plasma-estrone concentrations but it is not known whether these are of gonadal or adrenal origin. To answer this question, we measured plasma concentrations of testosterone, androstenedione, estradiol, estrone, and cortisol in 11 alcoholic men during sequential gonadal and adrenal suppression and stimulation. Basal testosterone in the 11 alcoholic men studied did not differ from that of the 22 age-sex matched controls. It declined 75% with gonadal suppression (fluoxymesterone 80 mg/day), remained unchanged with added adrenal suppression (dexamethasone 8 mg/day), and returned to normal with gonadal stimulation (human chorionic gonadotropin 5000 U/day). Basal estradiol levels in the alcoholic men also were normal and responded to suppression and stimulation in a manner that mirrored the testosterone responses. Basal estrone in the alcoholic men was double control values (p

Original languageEnglish (US)
Pages (from-to)536-541
Number of pages6
JournalMetabolism
Volume28
Issue number5
DOIs
Publication statusPublished - 1979
Externally publishedYes

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ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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