Evidence-based review of the literature on intrathecal delivery of pain medication

Gary Bennett, Mario Serafini, Kim Burchiel, Eric Buchser, Ashley Classen, Tim Deer, Stuart Du Pen, F. Michael Ferrante, Samuel J. Hassenbusch, Leland Lou, Jan Maeyaert, Richard Penn, Russell K. Portenoy, Richard Rauck, K. Dean Willis, Tony Yaksh

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Evidence-based medicine depends on the existence of controlled clinical trials that establish the safety and efficacy of specific therapeutic techniques. Many interventions in clinical practice have achieved widespread acceptance despite little evidence to support them in the scientific literature; the critical appraisal of these interventions based on accumulating experience is a goal of medicine. To clarify the current state of knowledge concerning the use of various drugs for intraspinal infusion in pain management, an expert panel conducted a thorough review of the published literature. The exhaustive review included 5 different groups of compounds, with morphine and bupivacaine yielding the most citations in the literature. The need for additional large published controlled studies was highlighted by this review, especially for promising agents that have been shown to be safe and efficacious in recent clinical studies. (C) U.S. Cancer Pain Relief Committee, 2000.

Original languageEnglish (US)
JournalJournal of Pain and Symptom Management
Volume20
Issue number2
DOIs
StatePublished - Aug 2000

Fingerprint

Literature
Evidence-Based Medicine
Bupivacaine
Controlled Clinical Trials
Pain Management
Morphine
Medicine
Safety
Pain
Pharmaceutical Preparations
Therapeutics
Cancer Pain
Clinical Studies

Keywords

  • Evidence-based medicine
  • Intraspinal infusion
  • Intrathecal
  • Pain management

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Neurology
  • Nursing(all)

Cite this

Evidence-based review of the literature on intrathecal delivery of pain medication. / Bennett, Gary; Serafini, Mario; Burchiel, Kim; Buchser, Eric; Classen, Ashley; Deer, Tim; Du Pen, Stuart; Ferrante, F. Michael; Hassenbusch, Samuel J.; Lou, Leland; Maeyaert, Jan; Penn, Richard; Portenoy, Russell K.; Rauck, Richard; Willis, K. Dean; Yaksh, Tony.

In: Journal of Pain and Symptom Management, Vol. 20, No. 2, 08.2000.

Research output: Contribution to journalArticle

Bennett, G, Serafini, M, Burchiel, K, Buchser, E, Classen, A, Deer, T, Du Pen, S, Ferrante, FM, Hassenbusch, SJ, Lou, L, Maeyaert, J, Penn, R, Portenoy, RK, Rauck, R, Willis, KD & Yaksh, T 2000, 'Evidence-based review of the literature on intrathecal delivery of pain medication', Journal of Pain and Symptom Management, vol. 20, no. 2. https://doi.org/10.1016/S0885-3924(00)00204-9
Bennett, Gary ; Serafini, Mario ; Burchiel, Kim ; Buchser, Eric ; Classen, Ashley ; Deer, Tim ; Du Pen, Stuart ; Ferrante, F. Michael ; Hassenbusch, Samuel J. ; Lou, Leland ; Maeyaert, Jan ; Penn, Richard ; Portenoy, Russell K. ; Rauck, Richard ; Willis, K. Dean ; Yaksh, Tony. / Evidence-based review of the literature on intrathecal delivery of pain medication. In: Journal of Pain and Symptom Management. 2000 ; Vol. 20, No. 2.
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