Abstract
Murine cytomegalovirus causes lifelong infections with little pathology in normal host animals. Control of viral replication and prevention of pathology depend on both innate and adaptive immune mechanisms, and cytolytic T lymphocytes play a key role in this process. The virus encodes a number of genes which alter the normal assembly of class I major histocompatability complex proteins, and thus interfere with the ability of infected cells to present antigen to CD8+ T cells. This review will examine what is known about these viral genes, and present some unanswered questions regarding the role of CTL evasion in the viral infectious cycle.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 19-26 |
| Number of pages | 8 |
| Journal | Seminars in Immunology |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2001 |
Keywords
- Cytotoxic T lymphocytes
- Immune evasion
- Major histocompatability complex class I
- Murine cytomegalovirus
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology