Evasion of cytotoxic T lymphocytes by murine cytomegalovirus

Daniel G. Kavanagh, Ann B. Hill

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Murine cytomegalovirus causes lifelong infections with little pathology in normal host animals. Control of viral replication and prevention of pathology depend on both innate and adaptive immune mechanisms, and cytolytic T lymphocytes play a key role in this process. The virus encodes a number of genes which alter the normal assembly of class I major histocompatability complex proteins, and thus interfere with the ability of infected cells to present antigen to CD8+ T cells. This review will examine what is known about these viral genes, and present some unanswered questions regarding the role of CTL evasion in the viral infectious cycle.

Original languageEnglish (US)
Pages (from-to)19-26
Number of pages8
JournalSeminars in Immunology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2001

Keywords

  • Cytotoxic T lymphocytes
  • Immune evasion
  • Major histocompatability complex class I
  • Murine cytomegalovirus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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