Evasion of adaptive and innate immune response mechanisms by γ-herpesviruses

Pinghui Feng, Ashlee Moses, Klaus Früh

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

γ-Herpesviral immune evasion mechanisms are optimized to support the acute, lytic and the longterm, latent phase of infection. During acute infection, specific immune modulatory proteins limit, but also exploit, the antiviral activities of cell intrinsic innate immune responses as well as those of innate and adaptive immune cells. During latent infection, a restricted gene expression program limits immune targeting and cis-acting mechanisms to reduce the antigen presentation as well as antigenicity of latency-associated proteins. Here, we will review recent progress in our understanding of γ-herpesviral immune evasion strategies.

Original languageEnglish (US)
Pages (from-to)285-295
Number of pages11
JournalCurrent Opinion in Virology
Volume3
Issue number3
DOIs
StatePublished - Jun 2013

ASJC Scopus subject areas

  • Virology

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