TY - JOUR
T1 - Evasion of adaptive and innate immune response mechanisms by γ-herpesviruses
AU - Feng, Pinghui
AU - Moses, Ashlee
AU - Früh, Klaus
PY - 2013/6
Y1 - 2013/6
N2 - γ-Herpesviral immune evasion mechanisms are optimized to support the acute, lytic and the longterm, latent phase of infection. During acute infection, specific immune modulatory proteins limit, but also exploit, the antiviral activities of cell intrinsic innate immune responses as well as those of innate and adaptive immune cells. During latent infection, a restricted gene expression program limits immune targeting and cis-acting mechanisms to reduce the antigen presentation as well as antigenicity of latency-associated proteins. Here, we will review recent progress in our understanding of γ-herpesviral immune evasion strategies.
AB - γ-Herpesviral immune evasion mechanisms are optimized to support the acute, lytic and the longterm, latent phase of infection. During acute infection, specific immune modulatory proteins limit, but also exploit, the antiviral activities of cell intrinsic innate immune responses as well as those of innate and adaptive immune cells. During latent infection, a restricted gene expression program limits immune targeting and cis-acting mechanisms to reduce the antigen presentation as well as antigenicity of latency-associated proteins. Here, we will review recent progress in our understanding of γ-herpesviral immune evasion strategies.
UR - http://www.scopus.com/inward/record.url?scp=84880288803&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880288803&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2013.05.011
DO - 10.1016/j.coviro.2013.05.011
M3 - Review article
C2 - 23735334
AN - SCOPUS:84880288803
SN - 1879-6257
VL - 3
SP - 285
EP - 295
JO - Current Opinion in Virology
JF - Current Opinion in Virology
IS - 3
ER -