TY - JOUR
T1 - Evaluation of vascular disease progression in retinopathy of prematurity using static and dynamic retinal images
AU - Myung, Jane S.
AU - Gelman, Rony
AU - Aaker, Grant D.
AU - Radcliffe, Nathan M.
AU - Chan, R. V.Paul
AU - Chiang, Michael F.
N1 - Funding Information:
All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Publication of this article was supported by grant EY19474 from the National Institutes of Health , Bethesda, Maryland (M.F.C.); by the St. Giles Foundation, New York, New York (R.V.P.C.); by departmental grants from Research to Prevent Blindness , New York, New York (R.V.P.C., N.M.R., J.S.M., G.D.A., M.F.C.); and by a grant from the Friends of Doernbecher foundation , Portland, Oregon (M.F.C.). M.F.C. is an unpaid member of the Scientific Advisory Board for Clarity Medical Systems. The authors have no commercial, proprietary, or financial interest in any of the products or companies described in this article. Involved in conception and design (M.F.C., R.V.P.C., N.M.R., J.S.M., G.D.A.); analysis and interpretation (M.F.C., R.V.P.C., N.M.R., J.S.M., R.G., G.D.A.); writing the article (M.F.C., J.S.M.); critical revision of the article (M.F.C., R.V.P.C., N.M.R., J.S.M., R.G., G.D.A.); final approval of the article (M.F.C., R.V.P.C., N.M.R., J.S.M., R.G., G.D.A.); data collection (M.F.C., J.S.M., R.G., G.D.A.); provision of materials, patients, or resources (M.F.C., R.V.P.C., N.M.R., R.G.); statistical expertise (M.F.C., R.V.P.C., R.G., J.S.M.); obtaining funding (M.F.C., R.V.P.C.); literature search (M.F.C., R.V.P.C., J.S.M.); and administrative, technical, or logistic support (M.F.C., R.V.P.C., N.M.R., R.G.). This research was approved by the Institutional Review Boards of Columbia University Medical Center and Weill Cornell Medical Center, and included a waiver of consent for use of de-identified retinal images. Informed consent was obtained from all expert study participants. All research was performed in compliance with the Health Insurance Portability and Accountability Act of 1996 and adhered to the tenets of the Declaration of Helsinki. The authors would like to acknowledge each of the expert participants for their contribution to this study.
PY - 2012/3
Y1 - 2012/3
N2 - • Purpose: To measure accuracy and speed for detection of vascular progression in retinopathy of prematurity (ROP) from serial images. Two strategies are compared: static side-by-side presentation and dynamic flickering of superimposed image pairs. • Design: Prospective comparative study. • Methods: Fifteen de-identified, wide-angle retinal image pairs were taken from infants who eventually developed plus disease. Image pairs representing vascular disease progression were taken ≥1 week apart, and control images without progression were taken on the same day. Dynamic flickering pairs were created by digital image registration. Ten experts independently reviewed each image pair on a secure website using both strategies, and were asked to identify progression or state that images were identical. Accuracy and speed were measured, using examination date and ophthalmoscopic findings as a reference standard. • Results: Using static images, experts were accurate in a mean (%) ± standard deviation (SD) of 11.4 of 15 (76%) ± 1.7 image pairs. Using dynamic flickering images, experts were accurate in a mean (%) ± SD of 11.3 of 15 (75%) ± 1.7 image pairs. There was no significant difference in accuracy between these strategies (P =.420). Diagnostic speed was faster using dynamic flickering (24.7 ± 8.3 seconds) vs static side-by-side images (40.3 ± 18.3 seconds) (P =.002). Experts reported higher confidence when interpreting dynamic flickering images (P =.001). • Conclusions: Retinal imaging provides objective documentation of vascular appearance, with potentially improved ability to recognize ROP progression compared to standard ophthalmoscopy. Speed of identifying vascular progression was faster by review of dynamic flickering image pairs than by static side-by-side images, although there was no difference in accuracy.
AB - • Purpose: To measure accuracy and speed for detection of vascular progression in retinopathy of prematurity (ROP) from serial images. Two strategies are compared: static side-by-side presentation and dynamic flickering of superimposed image pairs. • Design: Prospective comparative study. • Methods: Fifteen de-identified, wide-angle retinal image pairs were taken from infants who eventually developed plus disease. Image pairs representing vascular disease progression were taken ≥1 week apart, and control images without progression were taken on the same day. Dynamic flickering pairs were created by digital image registration. Ten experts independently reviewed each image pair on a secure website using both strategies, and were asked to identify progression or state that images were identical. Accuracy and speed were measured, using examination date and ophthalmoscopic findings as a reference standard. • Results: Using static images, experts were accurate in a mean (%) ± standard deviation (SD) of 11.4 of 15 (76%) ± 1.7 image pairs. Using dynamic flickering images, experts were accurate in a mean (%) ± SD of 11.3 of 15 (75%) ± 1.7 image pairs. There was no significant difference in accuracy between these strategies (P =.420). Diagnostic speed was faster using dynamic flickering (24.7 ± 8.3 seconds) vs static side-by-side images (40.3 ± 18.3 seconds) (P =.002). Experts reported higher confidence when interpreting dynamic flickering images (P =.001). • Conclusions: Retinal imaging provides objective documentation of vascular appearance, with potentially improved ability to recognize ROP progression compared to standard ophthalmoscopy. Speed of identifying vascular progression was faster by review of dynamic flickering image pairs than by static side-by-side images, although there was no difference in accuracy.
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U2 - 10.1016/j.ajo.2011.08.030
DO - 10.1016/j.ajo.2011.08.030
M3 - Article
C2 - 22019222
AN - SCOPUS:84857447889
VL - 153
SP - 544-551.e2
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 3
ER -