Evaluation of the relationship between heart rate and ventilation for epidemiologic studies

C. M. Mermier, J. M. Samet, William Lambert, T. W. Chick

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Estimation of pulmonary exposure and dose in air pollution epidemiology has been impaired by the lack of methods for directly measuring ventilation in ambulatory subjects. Heart-rate monitoring offers an approach to estimate ventilation by using ventilation-on-heart-rate (V(E)-HR) regressions established during exercise testing to estimate ventilation in the field. Conventional methods and protocols for testing were used to evaluate the relationship between V(E) and HR during three tasks: (1) exercising on a cycle ergometer, (2) lifting, and (3) vacuuming. The relationship between V(E) and HR was curvilinear and was best fit with linear regression models, using a natural log transformation of V(E). Considerable interindividual variability in slopes and intercepts was observed across all types of exercise tests. The variability about the fitted regression lines for individual subjects was minimal; for example, individual R2 values for the maximum exercise test on 15 men ranged from 0.90 to 0.99 (mean = 0.97). The regression slopes established during upper-body exercise were greater by approximately 30%, relative to those derived in lower-body exercise (paired t test, p <.001). However, V(E)-HR regression slopes derived from tests in which progressively increasing workloads were used were comparable to those obtained during variable and nonprogressive protocols. These findings indicate that predictive accuracy is maximized by deriving V(E)-HR regressions for individual subjects and for both lower- and upper-body activities.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalArchives of Environmental Health
Volume48
Issue number4
StatePublished - 1993
Externally publishedYes

Fingerprint

Ventilation
ventilation
Epidemiologic Studies
Heart Rate
Exercise
Exercise Test
Linear Models
Exercise equipment
Epidemiology
Air Pollution
Testing
epidemiology
Workload
Air pollution
Linear regression
evaluation
rate
atmospheric pollution
Lung
test

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Evaluation of the relationship between heart rate and ventilation for epidemiologic studies. / Mermier, C. M.; Samet, J. M.; Lambert, William; Chick, T. W.

In: Archives of Environmental Health, Vol. 48, No. 4, 1993, p. 263-269.

Research output: Contribution to journalArticle

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