Evaluation of serum cytokine release in response to hand-assisted, laparoscopic, and open surgery in a porcine model

Sean Orenstein, Gordie K. Kaban, Demetrius E. Litwin, Yuri W. Novitsky

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Although the immunologic benefits of laparoscopic surgery have been established, effects from hand-assisted (HA) surgery have not been investigated thoroughly. We hypothesized that the HA approach maintains the immunologic advantage of laparoscopic surgery compared with the open (O) approach. Methods: Six O, HA, and laparoscopic (L) transabdominal left nephrectomies were performed on pigs. Blood samples were taken preoperatively, perioperatively, and postoperatively, and serum interleukin-6 and C-reactive protein levels were measured. Results: At 24 hours after surgery, interleukin-6 levels were significantly higher in the O group vs the HA and L groups (82.2 vs 37.5 and 29.9 pg/mL, respectively; P

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalAmerican Journal of Surgery
Volume202
Issue number1
DOIs
StatePublished - Jul 2011
Externally publishedYes

Fingerprint

Hand-Assisted Laparoscopy
Swine
Hand
Cytokines
Serum
Laparoscopy
Interleukin-6
Nephrectomy
C-Reactive Protein

Keywords

  • C-reactive protein
  • Cytokine
  • Hand-assisted
  • Immunology
  • Interleukin-6
  • Laparoscopy
  • Laparotomy
  • Nephrectomy

ASJC Scopus subject areas

  • Surgery

Cite this

Evaluation of serum cytokine release in response to hand-assisted, laparoscopic, and open surgery in a porcine model. / Orenstein, Sean; Kaban, Gordie K.; Litwin, Demetrius E.; Novitsky, Yuri W.

In: American Journal of Surgery, Vol. 202, No. 1, 07.2011, p. 97-102.

Research output: Contribution to journalArticle

Orenstein, Sean ; Kaban, Gordie K. ; Litwin, Demetrius E. ; Novitsky, Yuri W. / Evaluation of serum cytokine release in response to hand-assisted, laparoscopic, and open surgery in a porcine model. In: American Journal of Surgery. 2011 ; Vol. 202, No. 1. pp. 97-102.
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