Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model

Qing Shuo Zhang, Laura Marquez-Loza, Andrea M. Sheehan, Kevin Watanabe-Smith, Laura Eaton, Eric Benedetti, Angela Major, Kathryn Schubert, Matthew Deater, Eric Joseph, Markus Grompe

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Fanconi anemia (FA) patients suffer from progressive bone marrow failure and often develop cancers. Previous studies showed that antioxidants tempol and resveratrol (RV) delayed tumor onset and reduced hematologic defects in FA murine models, respectively. Here we tested whether antioxidants N-acetylcysteine (NAC) or RV could delay cancer in tumor prone Fancd2-/-/Trp53+/- mice. Unlike tempol, neither compound had any significant chemopreventive effect in this model. We conclude that not all anti-oxidants are chemopreventive in FA. In addition, when given to Fancd2-/- mice, NAC helped maintain Fancd2-/- KSL cells in quiescence while tempol did not. The mechanisms behind the different actions of these antioxidants await further investigation. Pediatr Blood Cancer 2014;61:740-742.

Original languageEnglish (US)
Pages (from-to)740-742
Number of pages3
JournalPediatric Blood and Cancer
Volume61
Issue number4
DOIs
StatePublished - Apr 1 2014

Keywords

  • Antioxidants
  • Chemoprevention
  • Fanconi anemia
  • N-acetylcysteine
  • Resveratrol

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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    Zhang, Q. S., Marquez-Loza, L., Sheehan, A. M., Watanabe-Smith, K., Eaton, L., Benedetti, E., Major, A., Schubert, K., Deater, M., Joseph, E., & Grompe, M. (2014). Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model. Pediatric Blood and Cancer, 61(4), 740-742. https://doi.org/10.1002/pbc.24780