Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model

Qing Shuo Zhang; Laura Marquez-Loza; Andrea M. Sheehan; Kevin Watanabe-Smith; Laura Eaton; Eric Benedetti; Angela Major; Kathryn Schubert; Matthew Deater; Eric Joseph; Markus Grompe

doi:10.1002/pbc.24780

Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model

Qing Shuo Zhang, Laura Marquez-Loza, Andrea M. Sheehan, Kevin Watanabe-Smith, Laura Eaton, Eric Benedetti, Angela Major, Kathryn Schubert, Matthew Deater, Eric Joseph, Markus Grompe

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Fanconi anemia (FA) patients suffer from progressive bone marrow failure and often develop cancers. Previous studies showed that antioxidants tempol and resveratrol (RV) delayed tumor onset and reduced hematologic defects in FA murine models, respectively. Here we tested whether antioxidants N-acetylcysteine (NAC) or RV could delay cancer in tumor prone Fancd2^-/-/Trp53^+/- mice. Unlike tempol, neither compound had any significant chemopreventive effect in this model. We conclude that not all anti-oxidants are chemopreventive in FA. In addition, when given to Fancd2^-/- mice, NAC helped maintain Fancd2^-/- KSL cells in quiescence while tempol did not. The mechanisms behind the different actions of these antioxidants await further investigation. Pediatr Blood Cancer 2014;61:740-742.

Original language	English (US)
Pages (from-to)	740-742
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	61
Issue number	4
DOIs	https://doi.org/10.1002/pbc.24780
State	Published - Apr 2014

Keywords

Antioxidants
Chemoprevention
Fanconi anemia
N-acetylcysteine
Resveratrol

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.24780

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title = "Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model",

abstract = "Fanconi anemia (FA) patients suffer from progressive bone marrow failure and often develop cancers. Previous studies showed that antioxidants tempol and resveratrol (RV) delayed tumor onset and reduced hematologic defects in FA murine models, respectively. Here we tested whether antioxidants N-acetylcysteine (NAC) or RV could delay cancer in tumor prone Fancd2-/-/Trp53+/- mice. Unlike tempol, neither compound had any significant chemopreventive effect in this model. We conclude that not all anti-oxidants are chemopreventive in FA. In addition, when given to Fancd2-/- mice, NAC helped maintain Fancd2-/- KSL cells in quiescence while tempol did not. The mechanisms behind the different actions of these antioxidants await further investigation. Pediatr Blood Cancer 2014;61:740-742.",

keywords = "Antioxidants, Chemoprevention, Fanconi anemia, N-acetylcysteine, Resveratrol",

author = "Zhang, {Qing Shuo} and Laura Marquez-Loza and Sheehan, {Andrea M.} and Kevin Watanabe-Smith and Laura Eaton and Eric Benedetti and Angela Major and Kathryn Schubert and Matthew Deater and Eric Joseph and Markus Grompe",

year = "2014",

month = apr,

doi = "10.1002/pbc.24780",

language = "English (US)",

volume = "61",

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T1 - Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model

AU - Zhang, Qing Shuo

AU - Marquez-Loza, Laura

AU - Sheehan, Andrea M.

AU - Watanabe-Smith, Kevin

AU - Eaton, Laura

AU - Benedetti, Eric

AU - Major, Angela

AU - Schubert, Kathryn

AU - Deater, Matthew

AU - Joseph, Eric

AU - Grompe, Markus

PY - 2014/4

Y1 - 2014/4

N2 - Fanconi anemia (FA) patients suffer from progressive bone marrow failure and often develop cancers. Previous studies showed that antioxidants tempol and resveratrol (RV) delayed tumor onset and reduced hematologic defects in FA murine models, respectively. Here we tested whether antioxidants N-acetylcysteine (NAC) or RV could delay cancer in tumor prone Fancd2-/-/Trp53+/- mice. Unlike tempol, neither compound had any significant chemopreventive effect in this model. We conclude that not all anti-oxidants are chemopreventive in FA. In addition, when given to Fancd2-/- mice, NAC helped maintain Fancd2-/- KSL cells in quiescence while tempol did not. The mechanisms behind the different actions of these antioxidants await further investigation. Pediatr Blood Cancer 2014;61:740-742.

AB - Fanconi anemia (FA) patients suffer from progressive bone marrow failure and often develop cancers. Previous studies showed that antioxidants tempol and resveratrol (RV) delayed tumor onset and reduced hematologic defects in FA murine models, respectively. Here we tested whether antioxidants N-acetylcysteine (NAC) or RV could delay cancer in tumor prone Fancd2-/-/Trp53+/- mice. Unlike tempol, neither compound had any significant chemopreventive effect in this model. We conclude that not all anti-oxidants are chemopreventive in FA. In addition, when given to Fancd2-/- mice, NAC helped maintain Fancd2-/- KSL cells in quiescence while tempol did not. The mechanisms behind the different actions of these antioxidants await further investigation. Pediatr Blood Cancer 2014;61:740-742.

KW - Antioxidants

KW - Chemoprevention

KW - Fanconi anemia

KW - N-acetylcysteine

KW - Resveratrol

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Evaluation of resveratrol and N-acetylcysteine for cancer chemoprevention in a Fanconi anemia murine model

Abstract

Keywords

ASJC Scopus subject areas

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