Evaluation of Potential Systemic Adverse Events Related to Fluorescein Angiography in Pediatric Patients

Ru ik Chee, Mrinali P. Gupta, Nita G. Valikodath, Emily Cole, Anton Orlin, Tala Al-Khaled, Irene Rusu, Samir N. Patel, June Han, Vivien Yap, Karyn E. Jonas, Peter J. Campbell, Michael F. Chiang, R. V.Paul Chan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Purpose: To evaluate adverse events of fluorescein angiography (FA) in pediatric patients. Design: Single-institution retrospective chart review. Participants: Patients 0 to 18 years of age who underwent FA between January 2010 and December 2015 at a single institution in the United States. Methods: Pediatric patients who underwent FA by 3 surgeons were included in the study. Patients with fewer than 24 hours of documented follow-up were excluded. Significant adverse events within 24 hours of FA were evaluated. Detailed intraoperative and perioperative physiological parameters, including heart rate, blood pressure, oxygen saturation, and ventilation parameters, in inpatients undergoing simultaneous examination under anesthesia were reviewed. Peri-injection effects of FA were evaluated by 2-tailed paired t test comparison of mean 5-minute preinjection and 5-minute postinjection physiological data. Main Outcome Measures: Significant adverse events associated with FA. Results: One hundred fifteen patients with a total of 214 FA examinations were included. No significant adverse events were associated directly with FA. Comparison of mean 5-minute preinjection and postinjection physiologic parameters in 27 patients who underwent intravenous FA during EUA did not reveal significant changes associated with FA. A significant difference was found in average patient age between inpatient (2.5 years) and outpatient (10.7 years) FA (P < 0.00001). The youngest patients who underwent successful FA were 3.8 years old in the outpatient setting and 32 weeks’ postmenstrual age in the inpatient setting. Patients younger than 3.8 years accounted for most (77.6%; n = 85) inpatient FA examinations. Excluding patients with a need or likely need for laser or surgery, the reasons for inpatient FA in patients older than 3.8 years included the lack of availability of outpatient ultra-widefield FA (UWFA) and more challenging situations in patients with developmental delay. Conclusions: Fluorescein angiography was not found to be associated directly with systemic adverse events in pediatric patients in this study. Younger patients more commonly were found to require an inpatient FA, whereas older patients older than 4 years underwent outpatient UWFA.

Original languageEnglish (US)
Pages (from-to)595-601
Number of pages7
JournalOphthalmology Retina
Issue number6
StatePublished - Jun 2020

ASJC Scopus subject areas

  • Ophthalmology


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