Evaluation of port-wine stain treatment outcome using multi-spectral imaging

Ravikant Samatham, Niloy Choudhury, Alfons L. Krol, Steven L. Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Port-wine Stain (PWS) is a vascular malformation characterized by ectasia of superficial dermal capillaries. The flash-lamp pumped pulsed dye laser (PDL) treatment has been the mainstay of PWS for the last decade. Despite the success of the PDL in significantly fading the PWS, the overall cure rate is less than 10%. The precise efficacy of an individual PDL treatment is hard to evaluate and the treatment outcome is measured by visual observation of clinical fading. A hand-held multi-spectral imaging system was developed to image PWS before and after PDL treatment. In an NIH-funded pilot study multi-spectral camera was used to image PWS in children (2- 17 years). Oxygen saturation (S) and blood content (B) of PWS before and after the treatment was determined by analysis of the reflectance spectra. The outcome of the treatment was evaluated during follow up visits of the patients. One of the major causes of failure of laser therapy of port-wine stains (PWS) is reperfusion of the lesion after laser treatment. Oxygen saturation and blood content maps of PWS before and after treatment can predict regions of reperfusion and subsequent failure of the treatment. The ability to measure reperfusion and to predict lesions or areas susceptible to reperfusion, will help in selection of patients/lesions for laser treatment and help to optimize laser dosimetry for maximum effect. The current studies also should provide a basis for monitoring of future alternative therapies or enhancers of laser treatment in resistant cases.

Original languageEnglish (US)
Title of host publicationPhotonic Therapeutics and Diagnostics VIII
DOIs
StatePublished - May 14 2012
EventPhotonic Therapeutics and Diagnostics VIII - San Francisco, CA, United States
Duration: Jan 21 2012Jan 24 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8207
ISSN (Print)1605-7422

Other

OtherPhotonic Therapeutics and Diagnostics VIII
CountryUnited States
CitySan Francisco, CA
Period1/21/121/24/12

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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    Samatham, R., Choudhury, N., Krol, A. L., & Jacques, S. L. (2012). Evaluation of port-wine stain treatment outcome using multi-spectral imaging. In Photonic Therapeutics and Diagnostics VIII [82070C] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8207). https://doi.org/10.1117/12.909509