Evaluation of port-wine stain treatment outcome using multi-spectral imaging

Ravikant Samatham, Niloy Choudhury, Alfons Krol, Steven Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Port-wine Stain (PWS) is a vascular malformation characterized by ectasia of superficial dermal capillaries. The flash-lamp pumped pulsed dye laser (PDL) treatment has been the mainstay of PWS for the last decade. Despite the success of the PDL in significantly fading the PWS, the overall cure rate is less than 10%. The precise efficacy of an individual PDL treatment is hard to evaluate and the treatment outcome is measured by visual observation of clinical fading. A hand-held multi-spectral imaging system was developed to image PWS before and after PDL treatment. In an NIH-funded pilot study multi-spectral camera was used to image PWS in children (2- 17 years). Oxygen saturation (S) and blood content (B) of PWS before and after the treatment was determined by analysis of the reflectance spectra. The outcome of the treatment was evaluated during follow up visits of the patients. One of the major causes of failure of laser therapy of port-wine stains (PWS) is reperfusion of the lesion after laser treatment. Oxygen saturation and blood content maps of PWS before and after treatment can predict regions of reperfusion and subsequent failure of the treatment. The ability to measure reperfusion and to predict lesions or areas susceptible to reperfusion, will help in selection of patients/lesions for laser treatment and help to optimize laser dosimetry for maximum effect. The current studies also should provide a basis for monitoring of future alternative therapies or enhancers of laser treatment in resistant cases.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8207
DOIs
StatePublished - 2012
EventPhotonic Therapeutics and Diagnostics VIII - San Francisco, CA, United States
Duration: Jan 21 2012Jan 24 2012

Other

OtherPhotonic Therapeutics and Diagnostics VIII
CountryUnited States
CitySan Francisco, CA
Period1/21/121/24/12

Fingerprint

Port-Wine Stain
wines
Wine
Coloring Agents
Dye Lasers
Imaging techniques
Dye lasers
evaluation
Pulsed lasers
Reperfusion
Lasers
dye lasers
pulsed lasers
Therapeutics
lesions
lasers
Blood
fading
Oxygen
blood

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Samatham, R., Choudhury, N., Krol, A., & Jacques, S. (2012). Evaluation of port-wine stain treatment outcome using multi-spectral imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8207). [82070C] https://doi.org/10.1117/12.909509

Evaluation of port-wine stain treatment outcome using multi-spectral imaging. / Samatham, Ravikant; Choudhury, Niloy; Krol, Alfons; Jacques, Steven.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207 2012. 82070C.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Samatham, R, Choudhury, N, Krol, A & Jacques, S 2012, Evaluation of port-wine stain treatment outcome using multi-spectral imaging. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8207, 82070C, Photonic Therapeutics and Diagnostics VIII, San Francisco, CA, United States, 1/21/12. https://doi.org/10.1117/12.909509
Samatham R, Choudhury N, Krol A, Jacques S. Evaluation of port-wine stain treatment outcome using multi-spectral imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207. 2012. 82070C https://doi.org/10.1117/12.909509
Samatham, Ravikant ; Choudhury, Niloy ; Krol, Alfons ; Jacques, Steven. / Evaluation of port-wine stain treatment outcome using multi-spectral imaging. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207 2012.
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