Evaluation of pluronic polyols as carriers for grafting materials

Study in rat calvaria defects

Edward B. Fowler, Michael F. Cuenin, Steven Hokett, Mark E. Peacock, James D. McPherson, Thomas R. Dirksen, Mohamed Sharawy, Michael A. Billman

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: Pluronic polyols are a family of non-ionic surfactants currently used as drug carriers for antibiotic, anti-inflammatory, and anti-neoplastic agents. Therapeutic administration of non-ionic surface-active agents is known to facilitate early collagen synthesis and microcirculation, thus promoting wound healing. The purpose of this study was to determine the in vivo effects of pluronic polyols combined with either an allograft or an alloplast on the healing of critical-sized calvarial defects. Methods: One hundred fifty (150) adult (95 to 105 days old) male Sprague-Dawley rats weighing between 375 and 425 g were randomly and evenly assigned to each of 15 separate treatment groups and anesthetized, and 8 mm calvarial critical-sized defects were created. Pluronic F-68 (F-68) or pluronic F-127 (F-127) was administered either topically or systemically and in conjuction with demineralized bone powder (DBP), tricalcium phosphate (TCP), or non-grafted controls. Pluronic polyols are easily mixed with either DBP or TCP to improve handling ease. Calvaria were harvested at 12 weeks postsurgery and evaluated histomorphometrically, by contact radiography with subsequent densitometric analysis, through energy spectrometry utilizing a scanning electron microscope, and by fluorescent microscopy. Results: There was a significant difference in the percentage of bone fill among the control, TCP, and DBP only groups, P

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalJournal of Periodontology
Volume73
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Poloxamer
Skull
Powders
Bone and Bones
Surface-Active Agents
Drug Carriers
Microcirculation
Radiography
Wound Healing
Allografts
Sprague Dawley Rats
Microscopy
Spectrum Analysis
Anti-Inflammatory Agents
Collagen
polyol
Electrons
Anti-Bacterial Agents
Therapeutics
tricalcium phosphate

Keywords

  • Animals studies
  • Bone and bones
  • Grafts, bone
  • Surface active agents
  • Wound healing

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Fowler, E. B., Cuenin, M. F., Hokett, S., Peacock, M. E., McPherson, J. D., Dirksen, T. R., ... Billman, M. A. (2002). Evaluation of pluronic polyols as carriers for grafting materials: Study in rat calvaria defects. Journal of Periodontology, 73(2), 191-197. https://doi.org/10.1902/jop.2002.73.2.191

Evaluation of pluronic polyols as carriers for grafting materials : Study in rat calvaria defects. / Fowler, Edward B.; Cuenin, Michael F.; Hokett, Steven; Peacock, Mark E.; McPherson, James D.; Dirksen, Thomas R.; Sharawy, Mohamed; Billman, Michael A.

In: Journal of Periodontology, Vol. 73, No. 2, 2002, p. 191-197.

Research output: Contribution to journalArticle

Fowler, EB, Cuenin, MF, Hokett, S, Peacock, ME, McPherson, JD, Dirksen, TR, Sharawy, M & Billman, MA 2002, 'Evaluation of pluronic polyols as carriers for grafting materials: Study in rat calvaria defects', Journal of Periodontology, vol. 73, no. 2, pp. 191-197. https://doi.org/10.1902/jop.2002.73.2.191
Fowler, Edward B. ; Cuenin, Michael F. ; Hokett, Steven ; Peacock, Mark E. ; McPherson, James D. ; Dirksen, Thomas R. ; Sharawy, Mohamed ; Billman, Michael A. / Evaluation of pluronic polyols as carriers for grafting materials : Study in rat calvaria defects. In: Journal of Periodontology. 2002 ; Vol. 73, No. 2. pp. 191-197.
@article{bea2f3a530204d49a3ffd1f757fcc5c2,
title = "Evaluation of pluronic polyols as carriers for grafting materials: Study in rat calvaria defects",
abstract = "Background: Pluronic polyols are a family of non-ionic surfactants currently used as drug carriers for antibiotic, anti-inflammatory, and anti-neoplastic agents. Therapeutic administration of non-ionic surface-active agents is known to facilitate early collagen synthesis and microcirculation, thus promoting wound healing. The purpose of this study was to determine the in vivo effects of pluronic polyols combined with either an allograft or an alloplast on the healing of critical-sized calvarial defects. Methods: One hundred fifty (150) adult (95 to 105 days old) male Sprague-Dawley rats weighing between 375 and 425 g were randomly and evenly assigned to each of 15 separate treatment groups and anesthetized, and 8 mm calvarial critical-sized defects were created. Pluronic F-68 (F-68) or pluronic F-127 (F-127) was administered either topically or systemically and in conjuction with demineralized bone powder (DBP), tricalcium phosphate (TCP), or non-grafted controls. Pluronic polyols are easily mixed with either DBP or TCP to improve handling ease. Calvaria were harvested at 12 weeks postsurgery and evaluated histomorphometrically, by contact radiography with subsequent densitometric analysis, through energy spectrometry utilizing a scanning electron microscope, and by fluorescent microscopy. Results: There was a significant difference in the percentage of bone fill among the control, TCP, and DBP only groups, P",
keywords = "Animals studies, Bone and bones, Grafts, bone, Surface active agents, Wound healing",
author = "Fowler, {Edward B.} and Cuenin, {Michael F.} and Steven Hokett and Peacock, {Mark E.} and McPherson, {James D.} and Dirksen, {Thomas R.} and Mohamed Sharawy and Billman, {Michael A.}",
year = "2002",
doi = "10.1902/jop.2002.73.2.191",
language = "English (US)",
volume = "73",
pages = "191--197",
journal = "Journal of Periodontology",
issn = "0022-3492",
publisher = "American Academy of Periodontology",
number = "2",

}

TY - JOUR

T1 - Evaluation of pluronic polyols as carriers for grafting materials

T2 - Study in rat calvaria defects

AU - Fowler, Edward B.

AU - Cuenin, Michael F.

AU - Hokett, Steven

AU - Peacock, Mark E.

AU - McPherson, James D.

AU - Dirksen, Thomas R.

AU - Sharawy, Mohamed

AU - Billman, Michael A.

PY - 2002

Y1 - 2002

N2 - Background: Pluronic polyols are a family of non-ionic surfactants currently used as drug carriers for antibiotic, anti-inflammatory, and anti-neoplastic agents. Therapeutic administration of non-ionic surface-active agents is known to facilitate early collagen synthesis and microcirculation, thus promoting wound healing. The purpose of this study was to determine the in vivo effects of pluronic polyols combined with either an allograft or an alloplast on the healing of critical-sized calvarial defects. Methods: One hundred fifty (150) adult (95 to 105 days old) male Sprague-Dawley rats weighing between 375 and 425 g were randomly and evenly assigned to each of 15 separate treatment groups and anesthetized, and 8 mm calvarial critical-sized defects were created. Pluronic F-68 (F-68) or pluronic F-127 (F-127) was administered either topically or systemically and in conjuction with demineralized bone powder (DBP), tricalcium phosphate (TCP), or non-grafted controls. Pluronic polyols are easily mixed with either DBP or TCP to improve handling ease. Calvaria were harvested at 12 weeks postsurgery and evaluated histomorphometrically, by contact radiography with subsequent densitometric analysis, through energy spectrometry utilizing a scanning electron microscope, and by fluorescent microscopy. Results: There was a significant difference in the percentage of bone fill among the control, TCP, and DBP only groups, P

AB - Background: Pluronic polyols are a family of non-ionic surfactants currently used as drug carriers for antibiotic, anti-inflammatory, and anti-neoplastic agents. Therapeutic administration of non-ionic surface-active agents is known to facilitate early collagen synthesis and microcirculation, thus promoting wound healing. The purpose of this study was to determine the in vivo effects of pluronic polyols combined with either an allograft or an alloplast on the healing of critical-sized calvarial defects. Methods: One hundred fifty (150) adult (95 to 105 days old) male Sprague-Dawley rats weighing between 375 and 425 g were randomly and evenly assigned to each of 15 separate treatment groups and anesthetized, and 8 mm calvarial critical-sized defects were created. Pluronic F-68 (F-68) or pluronic F-127 (F-127) was administered either topically or systemically and in conjuction with demineralized bone powder (DBP), tricalcium phosphate (TCP), or non-grafted controls. Pluronic polyols are easily mixed with either DBP or TCP to improve handling ease. Calvaria were harvested at 12 weeks postsurgery and evaluated histomorphometrically, by contact radiography with subsequent densitometric analysis, through energy spectrometry utilizing a scanning electron microscope, and by fluorescent microscopy. Results: There was a significant difference in the percentage of bone fill among the control, TCP, and DBP only groups, P

KW - Animals studies

KW - Bone and bones

KW - Grafts, bone

KW - Surface active agents

KW - Wound healing

UR - http://www.scopus.com/inward/record.url?scp=0036199436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036199436&partnerID=8YFLogxK

U2 - 10.1902/jop.2002.73.2.191

DO - 10.1902/jop.2002.73.2.191

M3 - Article

VL - 73

SP - 191

EP - 197

JO - Journal of Periodontology

JF - Journal of Periodontology

SN - 0022-3492

IS - 2

ER -