Abstract
When the hypothesis of a link between vaccination and a possible adverse outcome arises, further investigation is required to confirm or refute the suspicion. Given the rarity of most serious adverse effects, a case-control approach will often be chosen. This paper discusses aspects of the design, analysis and interpretation of case-control studies to evaluate vaccine adverse effects. Potential biases (and how to minimise such biases) in the selection of cases and assessment of vaccine exposure and the potential for confounding are discussed. Finally the increasing use of electronic databases in the evaluation of vaccine adverse effects is considered.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2611-2617 |
| Number of pages | 7 |
| Journal | Vaccine |
| Volume | 20 |
| Issue number | 19-20 |
| DOIs | |
| State | Published - Jun 7 2002 |
| Externally published | Yes |
Fingerprint
Keywords
- Adverse effects
- Case-control
- Vaccines
ASJC Scopus subject areas
- Immunology
- Microbiology
- Virology
- Infectious Diseases
- Public Health, Environmental and Occupational Health
- veterinary(all)
Cite this
Evaluation of adverse effects of vaccines : The case-control approach. / Smeeth, Liam; Rodrigues, Laura C.; Hall, Andrew J.; Fombonne, Eric; Smith, Peter G.
In: Vaccine, Vol. 20, No. 19-20, 07.06.2002, p. 2611-2617.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of adverse effects of vaccines
T2 - The case-control approach
AU - Smeeth, Liam
AU - Rodrigues, Laura C.
AU - Hall, Andrew J.
AU - Fombonne, Eric
AU - Smith, Peter G.
PY - 2002/6/7
Y1 - 2002/6/7
N2 - When the hypothesis of a link between vaccination and a possible adverse outcome arises, further investigation is required to confirm or refute the suspicion. Given the rarity of most serious adverse effects, a case-control approach will often be chosen. This paper discusses aspects of the design, analysis and interpretation of case-control studies to evaluate vaccine adverse effects. Potential biases (and how to minimise such biases) in the selection of cases and assessment of vaccine exposure and the potential for confounding are discussed. Finally the increasing use of electronic databases in the evaluation of vaccine adverse effects is considered.
AB - When the hypothesis of a link between vaccination and a possible adverse outcome arises, further investigation is required to confirm or refute the suspicion. Given the rarity of most serious adverse effects, a case-control approach will often be chosen. This paper discusses aspects of the design, analysis and interpretation of case-control studies to evaluate vaccine adverse effects. Potential biases (and how to minimise such biases) in the selection of cases and assessment of vaccine exposure and the potential for confounding are discussed. Finally the increasing use of electronic databases in the evaluation of vaccine adverse effects is considered.
KW - Adverse effects
KW - Case-control
KW - Vaccines
UR - http://www.scopus.com/inward/record.url?scp=0037035875&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037035875&partnerID=8YFLogxK
U2 - 10.1016/S0264-410X(02)00147-0
DO - 10.1016/S0264-410X(02)00147-0
M3 - Article
C2 - 12057620
AN - SCOPUS:0037035875
VL - 20
SP - 2611
EP - 2617
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 19-20
ER -