TY - JOUR
T1 - Evaluating the endophenotype model of ADHD neuropsychological deficit
T2 - Results for parents and siblings of children with ADHD combined and inattentive subtypes
AU - Nigg, Joel T.
AU - Blaskey, Lisa G.
AU - Stawicki, Julie Ann
AU - Sachek, Jennifer
PY - 2004/11
Y1 - 2004/11
N2 - Neurogenetic models predict neuropsychological weaknesses in the relatives of children with attention-deficit/hyperactivity disorder (ADHD). The authors examined executive and regulatory measures in 386 relatives (307 parents, 79 siblings) of children with ADHD combined type, ADHD inattentive type, and controls. Predicted deficits were seen on trailmaking (relatives of ADHD combined type only), stop-signal reaction times (relatives of girls only), and response variability (mothers only) but not on naming or output speed. Effects generally held, even with relatives' ADHD status controlled. A neuropsychologically impaired subgroup of children with ADHD had relatives with clear neuropsychological weaknesses. The authors conclude that a neurogenetic model of ADHD etiology is supportable only for a subset of executive functions and that neuropsychological heterogeneity warrants more examination in ADHD.
AB - Neurogenetic models predict neuropsychological weaknesses in the relatives of children with attention-deficit/hyperactivity disorder (ADHD). The authors examined executive and regulatory measures in 386 relatives (307 parents, 79 siblings) of children with ADHD combined type, ADHD inattentive type, and controls. Predicted deficits were seen on trailmaking (relatives of ADHD combined type only), stop-signal reaction times (relatives of girls only), and response variability (mothers only) but not on naming or output speed. Effects generally held, even with relatives' ADHD status controlled. A neuropsychologically impaired subgroup of children with ADHD had relatives with clear neuropsychological weaknesses. The authors conclude that a neurogenetic model of ADHD etiology is supportable only for a subset of executive functions and that neuropsychological heterogeneity warrants more examination in ADHD.
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U2 - 10.1037/0021-843X.113.4.614
DO - 10.1037/0021-843X.113.4.614
M3 - Article
C2 - 15535793
AN - SCOPUS:7244231017
SN - 0021-843X
VL - 113
SP - 614
EP - 625
JO - Journal of Abnormal Psychology
JF - Journal of Abnormal Psychology
IS - 4
ER -