Evaluating the endophenotype model of ADHD neuropsychological deficit: Results for parents and siblings of children with ADHD combined and inattentive subtypes

Joel T. Nigg, Lisa G. Blaskey, Julie Ann Stawicki, Jennifer Sachek

Research output: Contribution to journalArticlepeer-review

135 Scopus citations

Abstract

Neurogenetic models predict neuropsychological weaknesses in the relatives of children with attention-deficit/hyperactivity disorder (ADHD). The authors examined executive and regulatory measures in 386 relatives (307 parents, 79 siblings) of children with ADHD combined type, ADHD inattentive type, and controls. Predicted deficits were seen on trailmaking (relatives of ADHD combined type only), stop-signal reaction times (relatives of girls only), and response variability (mothers only) but not on naming or output speed. Effects generally held, even with relatives' ADHD status controlled. A neuropsychologically impaired subgroup of children with ADHD had relatives with clear neuropsychological weaknesses. The authors conclude that a neurogenetic model of ADHD etiology is supportable only for a subset of executive functions and that neuropsychological heterogeneity warrants more examination in ADHD.

Original languageEnglish (US)
Pages (from-to)614-625
Number of pages12
JournalJournal of Abnormal Psychology
Volume113
Issue number4
DOIs
StatePublished - Nov 2004
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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