Evaluating outcomes of palliative photodynamic therapy: Instrument development and preliminary results

Teresa T. Goodell, Paulo R. Bargo, Steven Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Background: Subjective measures are considered the gold standard in palliative care evaluation, but no studies have evaluated palliative photodynamic therapy (PDT) subjectively. If PDT is to be accepted as a palliative therapy for later-stage obstructing esophageal and lung cancer, evidence of its effectiveness and acceptability to patients must be made known. Study Design/Materials and Methods: This ongoing study's major aim is to evaluate subjective outcomes of PDT in patients with obstructing esophageal and lung cancer. Existing measures of health status, dysphagia and performance status were supplemented with an instrument developed to evaluate PDT symptom relief and side effect burden, the PDT Side Effects Survey (PSES). Results: PDT patients treated with porfimer sodium (Photofrin®) and 630-nm light experienced reduced dysphagia grade and stable performance status for at least one month after PDT (N= 10-17), but these effects did not necessarily persist at three months. Fatigue, appetite and quality of life may be the most burdensome issues for these patients. Conclusions: Preliminary data suggest that the PSES is an acceptable and valid tool for measuring subjective outcomes of palliative PDT. This study is the first attempt to systematically evaluate subjective outcomes of palliative PDT. Multi-center outcomes research is needed to draw generalizable conclusions that will establish PDT's effectiveness in actual clinical practice and enhance the wider adoption of PDT as a cancer symptom relief modality.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsT.J. Dougherty
Pages1-12
Number of pages12
Volume4612
DOIs
StatePublished - 2002
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI - San Jose, CA, United States
Duration: Jan 19 2002Jan 20 2002

Other

OtherOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI
CountryUnited States
CitySan Jose, CA
Period1/19/021/20/02

Fingerprint

Photodynamic therapy
therapy
cancer
lungs
acceptability
health
grade
Sodium
Health
Fatigue of materials
sodium

Keywords

  • Dyspnea
  • Instrument Development
  • Outcomes Research
  • Palliation
  • Psychometrics
  • Symptom Measurement

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Goodell, T. T., Bargo, P. R., & Jacques, S. (2002). Evaluating outcomes of palliative photodynamic therapy: Instrument development and preliminary results. In T. J. Dougherty (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4612, pp. 1-12) https://doi.org/10.1117/12.469349

Evaluating outcomes of palliative photodynamic therapy : Instrument development and preliminary results. / Goodell, Teresa T.; Bargo, Paulo R.; Jacques, Steven.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / T.J. Dougherty. Vol. 4612 2002. p. 1-12.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Goodell, TT, Bargo, PR & Jacques, S 2002, Evaluating outcomes of palliative photodynamic therapy: Instrument development and preliminary results. in TJ Dougherty (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4612, pp. 1-12, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI, San Jose, CA, United States, 1/19/02. https://doi.org/10.1117/12.469349
Goodell TT, Bargo PR, Jacques S. Evaluating outcomes of palliative photodynamic therapy: Instrument development and preliminary results. In Dougherty TJ, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4612. 2002. p. 1-12 https://doi.org/10.1117/12.469349
Goodell, Teresa T. ; Bargo, Paulo R. ; Jacques, Steven. / Evaluating outcomes of palliative photodynamic therapy : Instrument development and preliminary results. Proceedings of SPIE - The International Society for Optical Engineering. editor / T.J. Dougherty. Vol. 4612 2002. pp. 1-12
@inproceedings{b3f6d41d63b64bd6838ba62ccaa6edaf,
title = "Evaluating outcomes of palliative photodynamic therapy: Instrument development and preliminary results",
abstract = "Background: Subjective measures are considered the gold standard in palliative care evaluation, but no studies have evaluated palliative photodynamic therapy (PDT) subjectively. If PDT is to be accepted as a palliative therapy for later-stage obstructing esophageal and lung cancer, evidence of its effectiveness and acceptability to patients must be made known. Study Design/Materials and Methods: This ongoing study's major aim is to evaluate subjective outcomes of PDT in patients with obstructing esophageal and lung cancer. Existing measures of health status, dysphagia and performance status were supplemented with an instrument developed to evaluate PDT symptom relief and side effect burden, the PDT Side Effects Survey (PSES). Results: PDT patients treated with porfimer sodium (Photofrin{\circledR}) and 630-nm light experienced reduced dysphagia grade and stable performance status for at least one month after PDT (N= 10-17), but these effects did not necessarily persist at three months. Fatigue, appetite and quality of life may be the most burdensome issues for these patients. Conclusions: Preliminary data suggest that the PSES is an acceptable and valid tool for measuring subjective outcomes of palliative PDT. This study is the first attempt to systematically evaluate subjective outcomes of palliative PDT. Multi-center outcomes research is needed to draw generalizable conclusions that will establish PDT's effectiveness in actual clinical practice and enhance the wider adoption of PDT as a cancer symptom relief modality.",
keywords = "Dyspnea, Instrument Development, Outcomes Research, Palliation, Psychometrics, Symptom Measurement",
author = "Goodell, {Teresa T.} and Bargo, {Paulo R.} and Steven Jacques",
year = "2002",
doi = "10.1117/12.469349",
language = "English (US)",
volume = "4612",
pages = "1--12",
editor = "T.J. Dougherty",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

TY - GEN

T1 - Evaluating outcomes of palliative photodynamic therapy

T2 - Instrument development and preliminary results

AU - Goodell, Teresa T.

AU - Bargo, Paulo R.

AU - Jacques, Steven

PY - 2002

Y1 - 2002

N2 - Background: Subjective measures are considered the gold standard in palliative care evaluation, but no studies have evaluated palliative photodynamic therapy (PDT) subjectively. If PDT is to be accepted as a palliative therapy for later-stage obstructing esophageal and lung cancer, evidence of its effectiveness and acceptability to patients must be made known. Study Design/Materials and Methods: This ongoing study's major aim is to evaluate subjective outcomes of PDT in patients with obstructing esophageal and lung cancer. Existing measures of health status, dysphagia and performance status were supplemented with an instrument developed to evaluate PDT symptom relief and side effect burden, the PDT Side Effects Survey (PSES). Results: PDT patients treated with porfimer sodium (Photofrin®) and 630-nm light experienced reduced dysphagia grade and stable performance status for at least one month after PDT (N= 10-17), but these effects did not necessarily persist at three months. Fatigue, appetite and quality of life may be the most burdensome issues for these patients. Conclusions: Preliminary data suggest that the PSES is an acceptable and valid tool for measuring subjective outcomes of palliative PDT. This study is the first attempt to systematically evaluate subjective outcomes of palliative PDT. Multi-center outcomes research is needed to draw generalizable conclusions that will establish PDT's effectiveness in actual clinical practice and enhance the wider adoption of PDT as a cancer symptom relief modality.

AB - Background: Subjective measures are considered the gold standard in palliative care evaluation, but no studies have evaluated palliative photodynamic therapy (PDT) subjectively. If PDT is to be accepted as a palliative therapy for later-stage obstructing esophageal and lung cancer, evidence of its effectiveness and acceptability to patients must be made known. Study Design/Materials and Methods: This ongoing study's major aim is to evaluate subjective outcomes of PDT in patients with obstructing esophageal and lung cancer. Existing measures of health status, dysphagia and performance status were supplemented with an instrument developed to evaluate PDT symptom relief and side effect burden, the PDT Side Effects Survey (PSES). Results: PDT patients treated with porfimer sodium (Photofrin®) and 630-nm light experienced reduced dysphagia grade and stable performance status for at least one month after PDT (N= 10-17), but these effects did not necessarily persist at three months. Fatigue, appetite and quality of life may be the most burdensome issues for these patients. Conclusions: Preliminary data suggest that the PSES is an acceptable and valid tool for measuring subjective outcomes of palliative PDT. This study is the first attempt to systematically evaluate subjective outcomes of palliative PDT. Multi-center outcomes research is needed to draw generalizable conclusions that will establish PDT's effectiveness in actual clinical practice and enhance the wider adoption of PDT as a cancer symptom relief modality.

KW - Dyspnea

KW - Instrument Development

KW - Outcomes Research

KW - Palliation

KW - Psychometrics

KW - Symptom Measurement

UR - http://www.scopus.com/inward/record.url?scp=0036402823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036402823&partnerID=8YFLogxK

U2 - 10.1117/12.469349

DO - 10.1117/12.469349

M3 - Conference contribution

AN - SCOPUS:0036402823

VL - 4612

SP - 1

EP - 12

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Dougherty, T.J.

ER -