Etretinate therapy stimulates deposition of mucus-like material in epidermis of patients with psoriasis

C. N. Ellis, R. C. Gold, R. C. Grekin, T. F. Anderson, Neil Swanson, J. J. Voorhees

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

During therapy for psoriasis with the oral aromatic retinoid etretinate, a finely granular material was detected by electron microscopic examination of the epidermis of ten patients. Since this amorphous substance has some of the ultrastructural characteristics of mucin, it is called mucus-like material (MLM). MLM occurs occasionally in untreated psoriatic lesions; however, its deposition is enhanced by etretinate therapy. While MLM has not been fully characterized, evidence exists for the possibilities that it represents either cell products (such as mucin, or carbohydrates associated with the cell surface) or an exudate infiltrating the epidermis.

Original languageEnglish (US)
Pages (from-to)699-704
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume6
Issue number4 II
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Etretinate
Mucus
Psoriasis
Epidermis
Mucins
Retinoids
Exudates and Transudates
Therapeutics
Carbohydrates
Electrons

ASJC Scopus subject areas

  • Dermatology

Cite this

Etretinate therapy stimulates deposition of mucus-like material in epidermis of patients with psoriasis. / Ellis, C. N.; Gold, R. C.; Grekin, R. C.; Anderson, T. F.; Swanson, Neil; Voorhees, J. J.

In: Journal of the American Academy of Dermatology, Vol. 6, No. 4 II, 1982, p. 699-704.

Research output: Contribution to journalArticle

Ellis, C. N. ; Gold, R. C. ; Grekin, R. C. ; Anderson, T. F. ; Swanson, Neil ; Voorhees, J. J. / Etretinate therapy stimulates deposition of mucus-like material in epidermis of patients with psoriasis. In: Journal of the American Academy of Dermatology. 1982 ; Vol. 6, No. 4 II. pp. 699-704.
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