Etiology of Delayed Puberty in 146 Children Evaluated Over a 10 Year Period

Patricia L. Krainz, Cheryl Hanna, Stephen Lafranchi

Research output: Contribution to journalArticle

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Abstract

To determine the etiology of delayed puberty in a referral population, we analyzed the clinical features and endocrine studies in 146 children seen between 1975 and 1985 whose pubertal onset was greater than 2 SD from the mean. Patients fell into 5 major categories: constitutional pubertal delay (46%), central nervous system problems resulting in hypothalamic-pituitary deficits (32%), primary gonadal failure (9%), underlying systemic disease (9%), and anatomic genitourinary tract anomalies (1.3%). Short stature was the most common presenting complaint both alone and as one of several complaints (84%), whereas delayed puberty as a single or one of several complaints was recognized in slightly less than half (43%) of our patients. Patients tended to be short, have a slow growth rate, eunuchoid body proportions and have a delayed bone age compared to means for chronologic age; these parameters corresponded better with means for bone age. Laboratory tests identified those with pituitary deficits and gonadal failure, but studies generally could not distinguish marked constitutional delay from isolated gonadotropin deficiency. Unlike previous surveys, most of our patients had constitutional delay often associated with a family history of delay, or an abnormality of the hypothalamic-pituitary axis either idiopathic or secondary to an intracranial tumor as the etiology of delayed puberty.

Original languageEnglish (US)
Pages (from-to)165-172
Number of pages8
JournalJournal of Pediatric Endocrinology and Metabolism
Volume2
Issue number4
DOIs
StatePublished - 1987

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Delayed Puberty
Bone and Bones
Gonadotropins
Referral and Consultation
Central Nervous System
Growth
Population
Neoplasms

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Etiology of Delayed Puberty in 146 Children Evaluated Over a 10 Year Period. / Krainz, Patricia L.; Hanna, Cheryl; Lafranchi, Stephen.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 2, No. 4, 1987, p. 165-172.

Research output: Contribution to journalArticle

Krainz, Patricia L. ; Hanna, Cheryl ; Lafranchi, Stephen. / Etiology of Delayed Puberty in 146 Children Evaluated Over a 10 Year Period. In: Journal of Pediatric Endocrinology and Metabolism. 1987 ; Vol. 2, No. 4. pp. 165-172.
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