Etiologies of Chronic Cough in Pediatric Cohorts: CHEST Guideline and Expert Panel Report

CHEST Expert Cough Panel

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background There is no published systematic review on the etiologies of chronic cough or the relationship between OSA and chronic cough in children aged ≤ 14 years. We thus undertook a systematic review based on key questions (KQs) using the Population, Intervention, Comparison, Outcome format. The KQs follow: Among children with chronic (> 4 weeks) cough (KQ 1) are the common etiologies different from those in adults? (KQ 2) Are the common etiologies age or setting dependent, or both? (KQ 3) Is OSA a cause of chronic cough in children? Methods We used the CHEST Expert Cough Panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form recommendations. Delphi methodology was used to obtain consensus. Results Combining KQs 1 and 2, we found moderate-level evidence from 10 prospective studies that the etiologies of cough in children are different from those in adults and are setting dependent. Data from three studies found that common etiologies of cough in young children were different from those in older children. However, data relating sleep abnormalities to chronic cough in children were found only in case studies. Conclusions There is moderate-quality evidence that common etiologies of chronic cough in children are different from those in adults and are dependent on age and setting. As there are few data relating OSA and chronic cough in children, the panel suggested that these children should be managed in accordance with pediatric sleep guidelines.

Original languageEnglish (US)
Pages (from-to)607-617
Number of pages11
JournalChest
Volume152
Issue number3
DOIs
StatePublished - Sep 1 2017

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Cough
Guidelines
Pediatrics
Sleep
Patient Preference
Consensus
Prospective Studies

Keywords

  • cough
  • evidence-based medicine
  • pediatrics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Etiologies of Chronic Cough in Pediatric Cohorts : CHEST Guideline and Expert Panel Report. / CHEST Expert Cough Panel.

In: Chest, Vol. 152, No. 3, 01.09.2017, p. 607-617.

Research output: Contribution to journalArticle

CHEST Expert Cough Panel. / Etiologies of Chronic Cough in Pediatric Cohorts : CHEST Guideline and Expert Panel Report. In: Chest. 2017 ; Vol. 152, No. 3. pp. 607-617.
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title = "Etiologies of Chronic Cough in Pediatric Cohorts: CHEST Guideline and Expert Panel Report",
abstract = "Background There is no published systematic review on the etiologies of chronic cough or the relationship between OSA and chronic cough in children aged ≤ 14 years. We thus undertook a systematic review based on key questions (KQs) using the Population, Intervention, Comparison, Outcome format. The KQs follow: Among children with chronic (> 4 weeks) cough (KQ 1) are the common etiologies different from those in adults? (KQ 2) Are the common etiologies age or setting dependent, or both? (KQ 3) Is OSA a cause of chronic cough in children? Methods We used the CHEST Expert Cough Panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form recommendations. Delphi methodology was used to obtain consensus. Results Combining KQs 1 and 2, we found moderate-level evidence from 10 prospective studies that the etiologies of cough in children are different from those in adults and are setting dependent. Data from three studies found that common etiologies of cough in young children were different from those in older children. However, data relating sleep abnormalities to chronic cough in children were found only in case studies. Conclusions There is moderate-quality evidence that common etiologies of chronic cough in children are different from those in adults and are dependent on age and setting. As there are few data relating OSA and chronic cough in children, the panel suggested that these children should be managed in accordance with pediatric sleep guidelines.",
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author = "{CHEST Expert Cough Panel} and Chang, {Anne B.} and Oppenheimer, {John J.} and Miles Weinberger and Grant, {Cameron C.} and Rubin, {Bruce K.} and Irwin, {Richard S.} and Altman, {Kenneth W.} and Elie Azoulay and Alan Barker and Birring, {Surinder S.} and Fiona Blackhall and Bolser, {Donald C.} and hristopher Brightling and Priscilla Callahan-Lyon and Chang, {Anne B.} and Paul Davenport and Satoru Ebihara and {El Solh}, {Ali A.} and Patricio Escalante and Field, {Stephen K.} and Dina Fisher and French, {Cynthia T.} and Harding, {Susan M.} and Peter Gibson and Philip Gold and Anthony Harnden and Hill, {Adam T.} and Irwin, {Richard S.} and Joanne Kavanagh and Keogh, {Karina A.} and Kefang Lai and Lane, {Andrew P.} and Madison, {J. Mark} and Malesker, {Mark A.} and Stuart Mazzone and Alex Molassoitis and Murad, {M. Hassan} and Mangala Narasimhan and Nguyen, {Huong Q.} and Peter Newcombe and John Oppenheimer and Restrepo, {Marcos I.} and Mark Rosen and Bruce Rubin and Ryu, {Jay H.} and Tarlo, {Susan M.} and Julie Turmel and Vertigan, {Anne E.} and Miles Weinberger and Kelly Weir",
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T1 - Etiologies of Chronic Cough in Pediatric Cohorts

T2 - CHEST Guideline and Expert Panel Report

AU - CHEST Expert Cough Panel

AU - Chang, Anne B.

AU - Oppenheimer, John J.

AU - Weinberger, Miles

AU - Grant, Cameron C.

AU - Rubin, Bruce K.

AU - Irwin, Richard S.

AU - Altman, Kenneth W.

AU - Azoulay, Elie

AU - Barker, Alan

AU - Birring, Surinder S.

AU - Blackhall, Fiona

AU - Bolser, Donald C.

AU - Brightling, hristopher

AU - Callahan-Lyon, Priscilla

AU - Chang, Anne B.

AU - Davenport, Paul

AU - Ebihara, Satoru

AU - El Solh, Ali A.

AU - Escalante, Patricio

AU - Field, Stephen K.

AU - Fisher, Dina

AU - French, Cynthia T.

AU - Harding, Susan M.

AU - Gibson, Peter

AU - Gold, Philip

AU - Harnden, Anthony

AU - Hill, Adam T.

AU - Irwin, Richard S.

AU - Kavanagh, Joanne

AU - Keogh, Karina A.

AU - Lai, Kefang

AU - Lane, Andrew P.

AU - Madison, J. Mark

AU - Malesker, Mark A.

AU - Mazzone, Stuart

AU - Molassoitis, Alex

AU - Murad, M. Hassan

AU - Narasimhan, Mangala

AU - Nguyen, Huong Q.

AU - Newcombe, Peter

AU - Oppenheimer, John

AU - Restrepo, Marcos I.

AU - Rosen, Mark

AU - Rubin, Bruce

AU - Ryu, Jay H.

AU - Tarlo, Susan M.

AU - Turmel, Julie

AU - Vertigan, Anne E.

AU - Weinberger, Miles

AU - Weir, Kelly

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background There is no published systematic review on the etiologies of chronic cough or the relationship between OSA and chronic cough in children aged ≤ 14 years. We thus undertook a systematic review based on key questions (KQs) using the Population, Intervention, Comparison, Outcome format. The KQs follow: Among children with chronic (> 4 weeks) cough (KQ 1) are the common etiologies different from those in adults? (KQ 2) Are the common etiologies age or setting dependent, or both? (KQ 3) Is OSA a cause of chronic cough in children? Methods We used the CHEST Expert Cough Panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form recommendations. Delphi methodology was used to obtain consensus. Results Combining KQs 1 and 2, we found moderate-level evidence from 10 prospective studies that the etiologies of cough in children are different from those in adults and are setting dependent. Data from three studies found that common etiologies of cough in young children were different from those in older children. However, data relating sleep abnormalities to chronic cough in children were found only in case studies. Conclusions There is moderate-quality evidence that common etiologies of chronic cough in children are different from those in adults and are dependent on age and setting. As there are few data relating OSA and chronic cough in children, the panel suggested that these children should be managed in accordance with pediatric sleep guidelines.

AB - Background There is no published systematic review on the etiologies of chronic cough or the relationship between OSA and chronic cough in children aged ≤ 14 years. We thus undertook a systematic review based on key questions (KQs) using the Population, Intervention, Comparison, Outcome format. The KQs follow: Among children with chronic (> 4 weeks) cough (KQ 1) are the common etiologies different from those in adults? (KQ 2) Are the common etiologies age or setting dependent, or both? (KQ 3) Is OSA a cause of chronic cough in children? Methods We used the CHEST Expert Cough Panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework. Data from the systematic reviews in conjunction with patients’ values and preferences and the clinical context were used to form recommendations. Delphi methodology was used to obtain consensus. Results Combining KQs 1 and 2, we found moderate-level evidence from 10 prospective studies that the etiologies of cough in children are different from those in adults and are setting dependent. Data from three studies found that common etiologies of cough in young children were different from those in older children. However, data relating sleep abnormalities to chronic cough in children were found only in case studies. Conclusions There is moderate-quality evidence that common etiologies of chronic cough in children are different from those in adults and are dependent on age and setting. As there are few data relating OSA and chronic cough in children, the panel suggested that these children should be managed in accordance with pediatric sleep guidelines.

KW - cough

KW - evidence-based medicine

KW - pediatrics

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