Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure

Ronald L. Alkana, Deborah (Deb) Finn, Guntwin G. Galleisky, Peter J. Syapin, Richard D. Malcolm

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Mice were fed an ethanol-containing liquid diet for 9 days. On removal of the diet, exposure to 12 atmospheres absolute of a mixture of helium and oxygen precipitated earlier withdrawal, increased withdrawal scores for the first 6 hours, and increased the peak withdrawal intensity compared to dependent animals exposed to control conditions. The enhanced withdrawal did not appear to reflect alterations in ethanol elimination, oxygen or helium partial pressures, body temperature, or general excitability. These results extend to chronically treated animals the evidence that hyperbaric exposure antagonizes the membrane actions of ethanol.

Original languageEnglish (US)
Pages (from-to)772-774
Number of pages3
JournalScience
Volume229
Issue number4715
StatePublished - 1985
Externally publishedYes

Fingerprint

Helium
Ethanol
Oxygen
Diet
Partial Pressure
Body Temperature
Atmosphere
Membranes

ASJC Scopus subject areas

  • General

Cite this

Alkana, R. L., Finn, D. D., Galleisky, G. G., Syapin, P. J., & Malcolm, R. D. (1985). Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure. Science, 229(4715), 772-774.

Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure. / Alkana, Ronald L.; Finn, Deborah (Deb); Galleisky, Guntwin G.; Syapin, Peter J.; Malcolm, Richard D.

In: Science, Vol. 229, No. 4715, 1985, p. 772-774.

Research output: Contribution to journalArticle

Alkana, RL, Finn, DD, Galleisky, GG, Syapin, PJ & Malcolm, RD 1985, 'Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure', Science, vol. 229, no. 4715, pp. 772-774.
Alkana RL, Finn DD, Galleisky GG, Syapin PJ, Malcolm RD. Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure. Science. 1985;229(4715):772-774.
Alkana, Ronald L. ; Finn, Deborah (Deb) ; Galleisky, Guntwin G. ; Syapin, Peter J. ; Malcolm, Richard D. / Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure. In: Science. 1985 ; Vol. 229, No. 4715. pp. 772-774.
@article{04e7e20c9d3d4b12b90011cd034b6f9b,
title = "Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure",
abstract = "Mice were fed an ethanol-containing liquid diet for 9 days. On removal of the diet, exposure to 12 atmospheres absolute of a mixture of helium and oxygen precipitated earlier withdrawal, increased withdrawal scores for the first 6 hours, and increased the peak withdrawal intensity compared to dependent animals exposed to control conditions. The enhanced withdrawal did not appear to reflect alterations in ethanol elimination, oxygen or helium partial pressures, body temperature, or general excitability. These results extend to chronically treated animals the evidence that hyperbaric exposure antagonizes the membrane actions of ethanol.",
author = "Alkana, {Ronald L.} and Finn, {Deborah (Deb)} and Galleisky, {Guntwin G.} and Syapin, {Peter J.} and Malcolm, {Richard D.}",
year = "1985",
language = "English (US)",
volume = "229",
pages = "772--774",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4715",

}

TY - JOUR

T1 - Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure

AU - Alkana, Ronald L.

AU - Finn, Deborah (Deb)

AU - Galleisky, Guntwin G.

AU - Syapin, Peter J.

AU - Malcolm, Richard D.

PY - 1985

Y1 - 1985

N2 - Mice were fed an ethanol-containing liquid diet for 9 days. On removal of the diet, exposure to 12 atmospheres absolute of a mixture of helium and oxygen precipitated earlier withdrawal, increased withdrawal scores for the first 6 hours, and increased the peak withdrawal intensity compared to dependent animals exposed to control conditions. The enhanced withdrawal did not appear to reflect alterations in ethanol elimination, oxygen or helium partial pressures, body temperature, or general excitability. These results extend to chronically treated animals the evidence that hyperbaric exposure antagonizes the membrane actions of ethanol.

AB - Mice were fed an ethanol-containing liquid diet for 9 days. On removal of the diet, exposure to 12 atmospheres absolute of a mixture of helium and oxygen precipitated earlier withdrawal, increased withdrawal scores for the first 6 hours, and increased the peak withdrawal intensity compared to dependent animals exposed to control conditions. The enhanced withdrawal did not appear to reflect alterations in ethanol elimination, oxygen or helium partial pressures, body temperature, or general excitability. These results extend to chronically treated animals the evidence that hyperbaric exposure antagonizes the membrane actions of ethanol.

UR - http://www.scopus.com/inward/record.url?scp=0021831295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021831295&partnerID=8YFLogxK

M3 - Article

C2 - 4040651

AN - SCOPUS:0021831295

VL - 229

SP - 772

EP - 774

JO - Science

JF - Science

SN - 0036-8075

IS - 4715

ER -