Ethanol Tolerance in a Genetically Insensitive Selected Mouse Line

Margaret Limm; John C. Crabbe

doi:10.1111/j.1530-0277.1992.tb00682.x

Ethanol Tolerance in a Genetically Insensitive Selected Mouse Line

Margaret Limm, John C. Crabbe

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Mouse lines genetically susceptible (COLD) or resistant (HOT) to the acute hypothermic effects of ethanol were previously shown to differ in tolerance development: HOT mice did not develop tolerance, while COLD mice did. The present experiment increased the thermal load on HOT and COLD mice by administering ethanol chronically at an ambient temperature of 4°C. Under these conditions, initial hypothermic responses were as large as 10°C. Both HOT and COLD mouse lines developed significant tolerance by the third daily injection. Tolerance was dose‐dependent: significant tolerance was seen only at the higher doses. HOT and COLD mouse lines developed approximately equal degrees of tolerance. Results support the hypothesis of a role for functional demand in the development of tolerance.

Original language	English (US)
Pages (from-to)	800-805
Number of pages	6
Journal	Alcoholism: Clinical and Experimental Research
Volume	16
Issue number	4
DOIs	https://doi.org/10.1111/j.1530-0277.1992.tb00682.x
State	Published - Aug 1992

Keywords

Ethanol
HOT/COLD Selected Lines
Hypothermia
Pharmacogenetics
Tolerance

ASJC Scopus subject areas

Medicine (miscellaneous)
Toxicology
Psychiatry and Mental health

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10.1111/j.1530-0277.1992.tb00682.x

Cite this

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abstract = "Mouse lines genetically susceptible (COLD) or resistant (HOT) to the acute hypothermic effects of ethanol were previously shown to differ in tolerance development: HOT mice did not develop tolerance, while COLD mice did. The present experiment increased the thermal load on HOT and COLD mice by administering ethanol chronically at an ambient temperature of 4°C. Under these conditions, initial hypothermic responses were as large as 10°C. Both HOT and COLD mouse lines developed significant tolerance by the third daily injection. Tolerance was dose‐dependent: significant tolerance was seen only at the higher doses. HOT and COLD mouse lines developed approximately equal degrees of tolerance. Results support the hypothesis of a role for functional demand in the development of tolerance.",

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AU - Limm, Margaret

AU - Crabbe, John C.

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AB - Mouse lines genetically susceptible (COLD) or resistant (HOT) to the acute hypothermic effects of ethanol were previously shown to differ in tolerance development: HOT mice did not develop tolerance, while COLD mice did. The present experiment increased the thermal load on HOT and COLD mice by administering ethanol chronically at an ambient temperature of 4°C. Under these conditions, initial hypothermic responses were as large as 10°C. Both HOT and COLD mouse lines developed significant tolerance by the third daily injection. Tolerance was dose‐dependent: significant tolerance was seen only at the higher doses. HOT and COLD mouse lines developed approximately equal degrees of tolerance. Results support the hypothesis of a role for functional demand in the development of tolerance.

KW - Ethanol

KW - HOT/COLD Selected Lines

KW - Hypothermia

KW - Pharmacogenetics

KW - Tolerance

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Ethanol Tolerance in a Genetically Insensitive Selected Mouse Line

Abstract

Keywords

ASJC Scopus subject areas

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