Ethanol tolerance in a genetically insensitive selected mouse line

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Mouse lines genetically susceptible (COLD) or resistant (HOT) to the acute hypothermic effects of ethanol were previously shown to differ in tolerance development: HOT mice did not develop tolerance, while COLD mice did. The present experiment increased the thermal load on HOT and COLD mice by administering ethanol chronically at an ambient temperature of 4°C. Under these conditions, initial hypothermic responses were as large as 10°C. Both HOT and COLD mouse lines developed significant tolerance by the third daily injection. Tolerance was dose-dependent: significant tolerance was seen only at the higher doses. HOT and COLD mouse lines developed approximately equal degrees of tolerance. Results support the hypothesis of a role for functional demand in the development of tolerance.

Original languageEnglish (US)
Pages (from-to)800-805
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume16
Issue number4
StatePublished - 1992

Fingerprint

Ethanol
Thermal load
Hot Temperature
Injections
Temperature
Experiments

Keywords

  • Ethanol
  • HOT/COLD Selected Lines
  • Hypothermia
  • Pharmacogenetics
  • Tolerance

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Ethanol tolerance in a genetically insensitive selected mouse line. / Limm, M.; Crabbe, John Jr.

In: Alcoholism: Clinical and Experimental Research, Vol. 16, No. 4, 1992, p. 800-805.

Research output: Contribution to journalArticle

@article{0daeee5b6836471d932f174d1aa98c1c,
title = "Ethanol tolerance in a genetically insensitive selected mouse line",
abstract = "Mouse lines genetically susceptible (COLD) or resistant (HOT) to the acute hypothermic effects of ethanol were previously shown to differ in tolerance development: HOT mice did not develop tolerance, while COLD mice did. The present experiment increased the thermal load on HOT and COLD mice by administering ethanol chronically at an ambient temperature of 4°C. Under these conditions, initial hypothermic responses were as large as 10°C. Both HOT and COLD mouse lines developed significant tolerance by the third daily injection. Tolerance was dose-dependent: significant tolerance was seen only at the higher doses. HOT and COLD mouse lines developed approximately equal degrees of tolerance. Results support the hypothesis of a role for functional demand in the development of tolerance.",
keywords = "Ethanol, HOT/COLD Selected Lines, Hypothermia, Pharmacogenetics, Tolerance",
author = "M. Limm and Crabbe, {John Jr}",
year = "1992",
language = "English (US)",
volume = "16",
pages = "800--805",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Ethanol tolerance in a genetically insensitive selected mouse line

AU - Limm, M.

AU - Crabbe, John Jr

PY - 1992

Y1 - 1992

N2 - Mouse lines genetically susceptible (COLD) or resistant (HOT) to the acute hypothermic effects of ethanol were previously shown to differ in tolerance development: HOT mice did not develop tolerance, while COLD mice did. The present experiment increased the thermal load on HOT and COLD mice by administering ethanol chronically at an ambient temperature of 4°C. Under these conditions, initial hypothermic responses were as large as 10°C. Both HOT and COLD mouse lines developed significant tolerance by the third daily injection. Tolerance was dose-dependent: significant tolerance was seen only at the higher doses. HOT and COLD mouse lines developed approximately equal degrees of tolerance. Results support the hypothesis of a role for functional demand in the development of tolerance.

AB - Mouse lines genetically susceptible (COLD) or resistant (HOT) to the acute hypothermic effects of ethanol were previously shown to differ in tolerance development: HOT mice did not develop tolerance, while COLD mice did. The present experiment increased the thermal load on HOT and COLD mice by administering ethanol chronically at an ambient temperature of 4°C. Under these conditions, initial hypothermic responses were as large as 10°C. Both HOT and COLD mouse lines developed significant tolerance by the third daily injection. Tolerance was dose-dependent: significant tolerance was seen only at the higher doses. HOT and COLD mouse lines developed approximately equal degrees of tolerance. Results support the hypothesis of a role for functional demand in the development of tolerance.

KW - Ethanol

KW - HOT/COLD Selected Lines

KW - Hypothermia

KW - Pharmacogenetics

KW - Tolerance

UR - http://www.scopus.com/inward/record.url?scp=0026731669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026731669&partnerID=8YFLogxK

M3 - Article

C2 - 1530144

AN - SCOPUS:0026731669

VL - 16

SP - 800

EP - 805

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 4

ER -