Ethanol Tolerance in a Genetically Insensitive Selected Mouse Line

Margaret Limm, John C. Crabbe

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Mouse lines genetically susceptible (COLD) or resistant (HOT) to the acute hypothermic effects of ethanol were previously shown to differ in tolerance development: HOT mice did not develop tolerance, while COLD mice did. The present experiment increased the thermal load on HOT and COLD mice by administering ethanol chronically at an ambient temperature of 4°C. Under these conditions, initial hypothermic responses were as large as 10°C. Both HOT and COLD mouse lines developed significant tolerance by the third daily injection. Tolerance was dose‐dependent: significant tolerance was seen only at the higher doses. HOT and COLD mouse lines developed approximately equal degrees of tolerance. Results support the hypothesis of a role for functional demand in the development of tolerance.

Original languageEnglish (US)
Pages (from-to)800-805
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume16
Issue number4
DOIs
StatePublished - Aug 1992

Keywords

  • Ethanol
  • HOT/COLD Selected Lines
  • Hypothermia
  • Pharmacogenetics
  • Tolerance

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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