TY - JOUR
T1 - Ethanol-induced conditioned place aversion in rats
T2 - Effect of interstimulus interval
AU - Bormann, Nancy M.
AU - Cunningham, Christopher L.
N1 - Funding Information:
This research was supported in part by NIAAA Grants AA07702 and AA07468. Portions of these data were presented at the annual meeting of the Research Society on Alcoholism (Steamboat Springs, CO; June, 1995).
PY - 1998/2
Y1 - 1998/2
N2 - The purpose of this study was to examine the effect of interstimulus interval (ISI) on ethanol-induced place aversion in rats. Six groups of rats initially received four pairings of a distinctive floor stimulus (CS+) with ethanol (1 g/kg, IP) and four pairings of a different floor stimulus (CS-) with saline. Groups -30, -15, -10, -5, 0, and 5 were injected 30, 15, 10, 5, or 0 min before, or 5 min after exposure to the 5 min CS, respectively. After testing for place aversion, all groups were exposed to an additional set of conditioning trials using a higher dose of ethanol (1.5 g/kg). During the first test, only groups 0 and -15 exhibited conditioned place aversion. However, during the second test, all groups showed conditioned aversion except group -30. The results suggest that ethanol's aversive effects dissipate by 30 min postinjection or that it is more difficult to associate those effects with short-duration external stimuli at long backward intervals. In contrast to recent findings with mice, the direction of ethanol-induced place conditioning was not altered in rats exposed to different ISIs.
AB - The purpose of this study was to examine the effect of interstimulus interval (ISI) on ethanol-induced place aversion in rats. Six groups of rats initially received four pairings of a distinctive floor stimulus (CS+) with ethanol (1 g/kg, IP) and four pairings of a different floor stimulus (CS-) with saline. Groups -30, -15, -10, -5, 0, and 5 were injected 30, 15, 10, 5, or 0 min before, or 5 min after exposure to the 5 min CS, respectively. After testing for place aversion, all groups were exposed to an additional set of conditioning trials using a higher dose of ethanol (1.5 g/kg). During the first test, only groups 0 and -15 exhibited conditioned place aversion. However, during the second test, all groups showed conditioned aversion except group -30. The results suggest that ethanol's aversive effects dissipate by 30 min postinjection or that it is more difficult to associate those effects with short-duration external stimuli at long backward intervals. In contrast to recent findings with mice, the direction of ethanol-induced place conditioning was not altered in rats exposed to different ISIs.
KW - Classical conditioning
KW - Conditioned place aversion
KW - Ethanol
KW - Interstimulus interval
KW - Locomotor activity
KW - Place conditioning
KW - Rats
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U2 - 10.1016/S0091-3057(97)00455-3
DO - 10.1016/S0091-3057(97)00455-3
M3 - Article
C2 - 9476991
AN - SCOPUS:0032005772
SN - 0091-3057
VL - 59
SP - 427
EP - 432
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 2
ER -