Ethanol dependence and the pituitary adrenal axis in mice II. Temporal analysis of dependence and withdrawal.

L. Donald Keith, John C. Crabbe, Linda M. Robertson, Emmett R. Young

Research output: Contribution to journalArticle

21 Scopus citations


The effects of ethanol dependence and withdrawal on pituitary hormone content and corticosterone release were investigated in AKR/J male mice in a vapor chamber. Both chronic ethanol inhalation and ethanol withdrawal were associated with increased adenohypophyseal-adrenocortical activity. Operationally, ethanol exposure was a stressor. Both physical dependence and withdrawal led to increased secretion/synthesis ratios of peptide hormones. The temporal pattern of pituitary ACTH-IR content changes was different from that of β-endorphin-IR and α-MSH-IR. Differences in the pattern of ACTH-IR and α-MSH-IR most probably represent lobe-specific differences in the response to chronic ethanol exposure and withdrawal.

Original languageEnglish (US)
Pages (from-to)1889-1897
Number of pages9
JournalLife Sciences
Issue number19
StatePublished - Nov 7 1983


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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