Ethanol dependence and the pituitary adrenal axis in mice II. Temporal analysis of dependence and withdrawal.

L. Donald Keith, John Jr Crabbe, Linda M. Robertson, Emmett R. Young

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The effects of ethanol dependence and withdrawal on pituitary hormone content and corticosterone release were investigated in AKR/J male mice in a vapor chamber. Both chronic ethanol inhalation and ethanol withdrawal were associated with increased adenohypophyseal-adrenocortical activity. Operationally, ethanol exposure was a stressor. Both physical dependence and withdrawal led to increased secretion/synthesis ratios of peptide hormones. The temporal pattern of pituitary ACTH-IR content changes was different from that of β-endorphin-IR and α-MSH-IR. Differences in the pattern of ACTH-IR and α-MSH-IR most probably represent lobe-specific differences in the response to chronic ethanol exposure and withdrawal.

Original languageEnglish (US)
Pages (from-to)1889-1897
Number of pages9
JournalLife Sciences
Volume33
Issue number19
DOIs
StatePublished - Nov 7 1983

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Ethanol
Melanocyte-Stimulating Hormones
Adrenocorticotropic Hormone
Endorphins
Pituitary Hormones
Peptide Hormones
Corticosterone
Inhalation
Vapors

ASJC Scopus subject areas

  • Pharmacology

Cite this

Ethanol dependence and the pituitary adrenal axis in mice II. Temporal analysis of dependence and withdrawal. / Keith, L. Donald; Crabbe, John Jr; Robertson, Linda M.; Young, Emmett R.

In: Life Sciences, Vol. 33, No. 19, 07.11.1983, p. 1889-1897.

Research output: Contribution to journalArticle

Keith, L. Donald ; Crabbe, John Jr ; Robertson, Linda M. ; Young, Emmett R. / Ethanol dependence and the pituitary adrenal axis in mice II. Temporal analysis of dependence and withdrawal. In: Life Sciences. 1983 ; Vol. 33, No. 19. pp. 1889-1897.
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