Ethanol consumption in the female Long-Evans rat: A modulatory role of estradiol

Matthew Ford, J. Charles Eldridge, Herman H. Samson

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The examination of various gonadal hormone manipulations on ethanol intake in human subjects and in rodent models has resulted in disparate findings. In the present study, we examined the effects of ovariectomy and subsequent estradiol (E2) replacement on ethanol intake in a within-subject design, as well as assessed the relevance of reproductive status on the efficacy of an E2 stimulus in eliciting consumption. Female Long-Evans rats (n = 24) were given access to 10% ethanol and water in a continuous-access paradigm. After establishment of baseline intake values, rats were divided into four groups: sham/placebo (Shm+P), sham/estradiol (Shm+E2), ovariectomized/placebo (Ovx+P), and ovariectomized/estradiol (Ovx+E2). Rats in the Ovx+P group were found to have a large and permanent decline in ethanol intake that persisted more than 3 months postsurgery. Administration of E2 to Ovx+E2 rats was associated with restoration of ethanol consumption to baseline levels. When Shm+E2 and Ovx+E2 groups were compared, reproductive status was found to be a determining factor in the efficacy of E2 to elicit ethanol intake. Together, these findings provide evidence that ovarian hormones, particularly estradiol, exert activational effects on estrogen-responsive substrates to modulate ethanol consumption in the adult female rat.

Original languageEnglish (US)
Pages (from-to)103-113
Number of pages11
JournalAlcohol
Volume26
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Long Evans Rats
Rats
Estradiol
Ethanol
Group
restoration
manipulation
stimulus
paradigm
Placebos
water
examination
Gonadal Hormones
Ovariectomy
evidence
Values
Restoration
Rodentia
Estrogens
Hormones

Keywords

  • Continuous access
  • Estradiol replacement
  • Ethanol self-administration
  • Female rat
  • Ovariectomy

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Behavioral Neuroscience
  • Neuroscience(all)
  • Toxicology
  • Health(social science)

Cite this

Ethanol consumption in the female Long-Evans rat : A modulatory role of estradiol. / Ford, Matthew; Eldridge, J. Charles; Samson, Herman H.

In: Alcohol, Vol. 26, No. 2, 2002, p. 103-113.

Research output: Contribution to journalArticle

Ford, Matthew ; Eldridge, J. Charles ; Samson, Herman H. / Ethanol consumption in the female Long-Evans rat : A modulatory role of estradiol. In: Alcohol. 2002 ; Vol. 26, No. 2. pp. 103-113.
@article{ed973f3ea2fb4b07969658a135b6f5f5,
title = "Ethanol consumption in the female Long-Evans rat: A modulatory role of estradiol",
abstract = "The examination of various gonadal hormone manipulations on ethanol intake in human subjects and in rodent models has resulted in disparate findings. In the present study, we examined the effects of ovariectomy and subsequent estradiol (E2) replacement on ethanol intake in a within-subject design, as well as assessed the relevance of reproductive status on the efficacy of an E2 stimulus in eliciting consumption. Female Long-Evans rats (n = 24) were given access to 10{\%} ethanol and water in a continuous-access paradigm. After establishment of baseline intake values, rats were divided into four groups: sham/placebo (Shm+P), sham/estradiol (Shm+E2), ovariectomized/placebo (Ovx+P), and ovariectomized/estradiol (Ovx+E2). Rats in the Ovx+P group were found to have a large and permanent decline in ethanol intake that persisted more than 3 months postsurgery. Administration of E2 to Ovx+E2 rats was associated with restoration of ethanol consumption to baseline levels. When Shm+E2 and Ovx+E2 groups were compared, reproductive status was found to be a determining factor in the efficacy of E2 to elicit ethanol intake. Together, these findings provide evidence that ovarian hormones, particularly estradiol, exert activational effects on estrogen-responsive substrates to modulate ethanol consumption in the adult female rat.",
keywords = "Continuous access, Estradiol replacement, Ethanol self-administration, Female rat, Ovariectomy",
author = "Matthew Ford and Eldridge, {J. Charles} and Samson, {Herman H.}",
year = "2002",
doi = "10.1016/S0741-8329(01)00203-8",
language = "English (US)",
volume = "26",
pages = "103--113",
journal = "Alcohol",
issn = "0741-8329",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Ethanol consumption in the female Long-Evans rat

T2 - A modulatory role of estradiol

AU - Ford, Matthew

AU - Eldridge, J. Charles

AU - Samson, Herman H.

PY - 2002

Y1 - 2002

N2 - The examination of various gonadal hormone manipulations on ethanol intake in human subjects and in rodent models has resulted in disparate findings. In the present study, we examined the effects of ovariectomy and subsequent estradiol (E2) replacement on ethanol intake in a within-subject design, as well as assessed the relevance of reproductive status on the efficacy of an E2 stimulus in eliciting consumption. Female Long-Evans rats (n = 24) were given access to 10% ethanol and water in a continuous-access paradigm. After establishment of baseline intake values, rats were divided into four groups: sham/placebo (Shm+P), sham/estradiol (Shm+E2), ovariectomized/placebo (Ovx+P), and ovariectomized/estradiol (Ovx+E2). Rats in the Ovx+P group were found to have a large and permanent decline in ethanol intake that persisted more than 3 months postsurgery. Administration of E2 to Ovx+E2 rats was associated with restoration of ethanol consumption to baseline levels. When Shm+E2 and Ovx+E2 groups were compared, reproductive status was found to be a determining factor in the efficacy of E2 to elicit ethanol intake. Together, these findings provide evidence that ovarian hormones, particularly estradiol, exert activational effects on estrogen-responsive substrates to modulate ethanol consumption in the adult female rat.

AB - The examination of various gonadal hormone manipulations on ethanol intake in human subjects and in rodent models has resulted in disparate findings. In the present study, we examined the effects of ovariectomy and subsequent estradiol (E2) replacement on ethanol intake in a within-subject design, as well as assessed the relevance of reproductive status on the efficacy of an E2 stimulus in eliciting consumption. Female Long-Evans rats (n = 24) were given access to 10% ethanol and water in a continuous-access paradigm. After establishment of baseline intake values, rats were divided into four groups: sham/placebo (Shm+P), sham/estradiol (Shm+E2), ovariectomized/placebo (Ovx+P), and ovariectomized/estradiol (Ovx+E2). Rats in the Ovx+P group were found to have a large and permanent decline in ethanol intake that persisted more than 3 months postsurgery. Administration of E2 to Ovx+E2 rats was associated with restoration of ethanol consumption to baseline levels. When Shm+E2 and Ovx+E2 groups were compared, reproductive status was found to be a determining factor in the efficacy of E2 to elicit ethanol intake. Together, these findings provide evidence that ovarian hormones, particularly estradiol, exert activational effects on estrogen-responsive substrates to modulate ethanol consumption in the adult female rat.

KW - Continuous access

KW - Estradiol replacement

KW - Ethanol self-administration

KW - Female rat

KW - Ovariectomy

UR - http://www.scopus.com/inward/record.url?scp=0036238221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036238221&partnerID=8YFLogxK

U2 - 10.1016/S0741-8329(01)00203-8

DO - 10.1016/S0741-8329(01)00203-8

M3 - Article

C2 - 12007585

AN - SCOPUS:0036238221

VL - 26

SP - 103

EP - 113

JO - Alcohol

JF - Alcohol

SN - 0741-8329

IS - 2

ER -