Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

Gil Benedek; Jun Zhang; Ha Nguyen; Gail Kent; Hilary A. Seifert; Sean Davin; Patrick Stauffer; Arthur A. Vandenbark; Lisa Karstens; Mark Asquith; Halina Offner

doi:10.1016/j.jneuroim.2017.06.007

Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

Gil Benedek, Jun Zhang, Ha Nguyen, Gail Kent, Hilary A. Seifert, Sean Davin, Patrick Stauffer, Arthur A. Vandenbark, Lisa Karstens, Mark Asquith, Halina Offner

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current study we evaluated the composition of the gut microbiota and the mucosal-associated regulatory cells in estrogen or sham treated female mice before and after autoimmune encephalomyelitis (EAE) induction. Treatment with pregnancy levels of estrogen induces changes in the composition and diversity of gut microbiota. Additionally, estrogen prevents EAE-associated changes in the gut microbiota and might promote the enrichment of bacteria that are associated with immune regulation. Our results point to a possible cross-talk between the sex hormones and the gut microbiota, which could promote neuroprotection.

Original language	English (US)
Pages (from-to)	51-59
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	310
DOIs	https://doi.org/10.1016/j.jneuroim.2017.06.007
State	Published - Sep 15 2017

Keywords

EAE
Estrogen
M2-like macrophage/microglia
Microbiota
Regulatory B cell

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2017.06.007

Cite this

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title = "Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells",

abstract = "Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current study we evaluated the composition of the gut microbiota and the mucosal-associated regulatory cells in estrogen or sham treated female mice before and after autoimmune encephalomyelitis (EAE) induction. Treatment with pregnancy levels of estrogen induces changes in the composition and diversity of gut microbiota. Additionally, estrogen prevents EAE-associated changes in the gut microbiota and might promote the enrichment of bacteria that are associated with immune regulation. Our results point to a possible cross-talk between the sex hormones and the gut microbiota, which could promote neuroprotection.",

keywords = "EAE, Estrogen, M2-like macrophage/microglia, Microbiota, Regulatory B cell",

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T1 - Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

AU - Benedek, Gil

AU - Zhang, Jun

AU - Nguyen, Ha

AU - Kent, Gail

AU - Seifert, Hilary A.

AU - Davin, Sean

AU - Stauffer, Patrick

AU - Vandenbark, Arthur A.

AU - Karstens, Lisa

AU - Asquith, Mark

AU - Offner, Halina

PY - 2017/9/15

Y1 - 2017/9/15

N2 - Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current study we evaluated the composition of the gut microbiota and the mucosal-associated regulatory cells in estrogen or sham treated female mice before and after autoimmune encephalomyelitis (EAE) induction. Treatment with pregnancy levels of estrogen induces changes in the composition and diversity of gut microbiota. Additionally, estrogen prevents EAE-associated changes in the gut microbiota and might promote the enrichment of bacteria that are associated with immune regulation. Our results point to a possible cross-talk between the sex hormones and the gut microbiota, which could promote neuroprotection.

AB - Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current study we evaluated the composition of the gut microbiota and the mucosal-associated regulatory cells in estrogen or sham treated female mice before and after autoimmune encephalomyelitis (EAE) induction. Treatment with pregnancy levels of estrogen induces changes in the composition and diversity of gut microbiota. Additionally, estrogen prevents EAE-associated changes in the gut microbiota and might promote the enrichment of bacteria that are associated with immune regulation. Our results point to a possible cross-talk between the sex hormones and the gut microbiota, which could promote neuroprotection.

KW - EAE

KW - Estrogen

KW - M2-like macrophage/microglia

KW - Microbiota

KW - Regulatory B cell

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ER -

Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

Abstract

Keywords

ASJC Scopus subject areas

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