Abstract
Sex hormones promote immunoregulatory effects on multiple sclerosis. The current study evaluated estrogen effects on regulatory B cells and resident CNS microglia during experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen-dependent induction of multiple regulatory B cell markers indicative of IL-10 dependent as well as IFN-γ dependent pathways. Moreover, although estrogen pretreatment of EAE mice inhibited the infiltration of pro-inflammatory cells into the CNS, it enhanced the frequency of regulatory B cells and M2 microglia. Our study suggests that estrogen has a broad effect on the development of regulatory B cells during EAE, which in turn could promote neuroprotection.
Original language | English (US) |
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Pages (from-to) | 45-53 |
Number of pages | 9 |
Journal | Journal of Neuroimmunology |
Volume | 293 |
DOIs | |
State | Published - Apr 15 2016 |
Keywords
- EAE
- Estrogen
- IFN-γ
- IL-10
- Microglia
- Regulatory B cell
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology