Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis

Gil Benedek, Jun Zhang, Sheetal Bodhankar, Ha Nguyen, Gail Kent, Kelley Jordan, Dustin Manning, Arthur A. Vandenbark, Halina Offner

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Sex hormones promote immunoregulatory effects on multiple sclerosis. The current study evaluated estrogen effects on regulatory B cells and resident CNS microglia during experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen-dependent induction of multiple regulatory B cell markers indicative of IL-10 dependent as well as IFN-γ dependent pathways. Moreover, although estrogen pretreatment of EAE mice inhibited the infiltration of pro-inflammatory cells into the CNS, it enhanced the frequency of regulatory B cells and M2 microglia. Our study suggests that estrogen has a broad effect on the development of regulatory B cells during EAE, which in turn could promote neuroprotection.

Original languageEnglish (US)
Pages (from-to)45-53
Number of pages9
JournalJournal of Neuroimmunology
Volume293
DOIs
StatePublished - Apr 15 2016

Keywords

  • EAE
  • Estrogen
  • IFN-γ
  • IL-10
  • Microglia
  • Regulatory B cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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