Estrogen-induced prolactin and DNA synthesis in immature female rat pituitaries

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Estradiol is likely involved in stimulating developmental changes in the ability of the rat pituitary to secrete prolactin. To investigate the possibility that these changes involve proliferation of prolactin cells, estradiol effects on pituitary growth and prolactin synthesis were examined. Estradiol treatment of immature female rats stimulates increases in pituitary weight, [3H]thymidine incorporation, DNA content and prolactin synthesis. Treatment of rats with the DNA synthesis inhibitor, hydroxyurea, partially blocked the ability of estradiol to stimulate prolactin synthesis suggesting that at least part of the effect of estrogen is due to cell proliferation. These results suggest that estrogen-induced proliferation of prolactin cells is involved in the developmental processes of the pituitary.

Original languageEnglish (US)
Pages (from-to)291-300
Number of pages10
JournalMolecular and Cellular Endocrinology
Volume13
Issue number3
DOIs
StatePublished - 1979
Externally publishedYes

Fingerprint

Prolactin
Rats
Estrogens
Estradiol
DNA
Cell Proliferation
Nucleic Acid Synthesis Inhibitors
Hydroxyurea
Cell proliferation
Thymidine
Weights and Measures
Growth

Keywords

  • cell proliferation
  • hydroxyurea
  • [H]thymidine incorporation

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Estrogen-induced prolactin and DNA synthesis in immature female rat pituitaries. / Maurer, Richard.

In: Molecular and Cellular Endocrinology, Vol. 13, No. 3, 1979, p. 291-300.

Research output: Contribution to journalArticle

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