Estimation of regurgitant flow volume based on centerline velocity/distance profiles using digital color M-Q Doppler: Application to orifices of different shapes

Takahiro Shiota, Dag Teien, You Bin Deng, Shuping Ge, Robin Shandas, Scott Holcomb, David Sahn

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Abstract

Objectives. In this study we investigated the centerline velocity profile method for flow computation as applied to noncircular, as well as circular, orifices using digital color flow data. Background. Recently it has been suggested that flow volume through an orifice can be estimated more accurately by computing the axial "centerline" flow velocity/distance profile proximal to the orifice. Methods. A total of seven different orifices were mounted in a constant-flow model: four circular orifices, two rectangular orifices with a major/minor axis ratio of 4:1 and 8:1 and an ovoid orifice having a major/minor axis ratio of 2:1. Three different flow rates were examined (1.68, 3.48 and 6.48 liters/min). Digital measurements of flow velocity at discrete positions along the centerline progressing toward the orifice were analyzed to yield complete flow velocity profiles for each orifice at each flow rate. Results. A clear separation of the flow profiles for the three different flow rates was observed independent of orifice size for all of the circular orifices. The velocity/distance acceleration curves showed highly significant correlations using multiplicative regression fits (y = ax-b, r = 0.94 to 0.99, all p <0.0001). An equation for quantitatively correlating the a and b coefficients from the multiplicative regression fits with flow rates was derived from stepwise regression analysis: Flow rate = 23a + 3.3b - 1.5 (r = 0.97, p <0.0001, SEE 0.46 liter/min). Conclusions. In view of the various sizes and shapes encountered clinically for regurgitant orifices, the simplicity of this method for the estimation of the severity of regurgitant lesions might be of importance for clinical applications of this method.

Original languageEnglish (US)
Pages (from-to)440-445
Number of pages6
JournalJournal of the American College of Cardiology
Volume24
Issue number2
DOIs
StatePublished - 1994

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Regression Analysis

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Estimation of regurgitant flow volume based on centerline velocity/distance profiles using digital color M-Q Doppler : Application to orifices of different shapes. / Shiota, Takahiro; Teien, Dag; Deng, You Bin; Ge, Shuping; Shandas, Robin; Holcomb, Scott; Sahn, David.

In: Journal of the American College of Cardiology, Vol. 24, No. 2, 1994, p. 440-445.

Research output: Contribution to journalArticle

Shiota, Takahiro ; Teien, Dag ; Deng, You Bin ; Ge, Shuping ; Shandas, Robin ; Holcomb, Scott ; Sahn, David. / Estimation of regurgitant flow volume based on centerline velocity/distance profiles using digital color M-Q Doppler : Application to orifices of different shapes. In: Journal of the American College of Cardiology. 1994 ; Vol. 24, No. 2. pp. 440-445.
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abstract = "Objectives. In this study we investigated the centerline velocity profile method for flow computation as applied to noncircular, as well as circular, orifices using digital color flow data. Background. Recently it has been suggested that flow volume through an orifice can be estimated more accurately by computing the axial {"}centerline{"} flow velocity/distance profile proximal to the orifice. Methods. A total of seven different orifices were mounted in a constant-flow model: four circular orifices, two rectangular orifices with a major/minor axis ratio of 4:1 and 8:1 and an ovoid orifice having a major/minor axis ratio of 2:1. Three different flow rates were examined (1.68, 3.48 and 6.48 liters/min). Digital measurements of flow velocity at discrete positions along the centerline progressing toward the orifice were analyzed to yield complete flow velocity profiles for each orifice at each flow rate. Results. A clear separation of the flow profiles for the three different flow rates was observed independent of orifice size for all of the circular orifices. The velocity/distance acceleration curves showed highly significant correlations using multiplicative regression fits (y = ax-b, r = 0.94 to 0.99, all p <0.0001). An equation for quantitatively correlating the a and b coefficients from the multiplicative regression fits with flow rates was derived from stepwise regression analysis: Flow rate = 23a + 3.3b - 1.5 (r = 0.97, p <0.0001, SEE 0.46 liter/min). Conclusions. In view of the various sizes and shapes encountered clinically for regurgitant orifices, the simplicity of this method for the estimation of the severity of regurgitant lesions might be of importance for clinical applications of this method.",
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