TY - JOUR
T1 - Estimation of regurgitant flow volume based on centerline velocity/distance profiles using digital color M-Q Doppler
T2 - Application to orifices of different shapes
AU - Shiota, Takahiro
AU - Teien, Dag
AU - Deng, You Bin
AU - Ge, Shuping
AU - Shandas, Robin
AU - Holcomb, Scott
AU - Sahn, David J.
N1 - Funding Information:
From the Clinical Care Center for Congenital Heart Disease, Oregon Health Sciences University, Portland, Oregon. This study was supported in part by Grant R01HL43287 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland . Manuscript received July 7, 1993 ; revised manuscript received March 8 . 1994, accepted March 16, 1994. Address for correspondence ; Dr. David J. Sahn, Clinical Care Center for Congenital Heart Disease, 3181 SW Sam Jackson Park Road, Oregon Health Sciences University, Mail Code UHN 60, Portland, Oregon 97201 .
PY - 1994/8
Y1 - 1994/8
N2 - Objectives. In this study we investigated the centerline velocity profile method for flow computation as applied to noncircular, as well as circular, orifices using digital color flow data. Background. Recently it has been suggested that flow volume through an orifice can be estimated more accurately by computing the axial "centerline" flow velocity/distance profile proximal to the orifice. Methods. A total of seven different orifices were mounted in a constant-flow model: four circular orifices, two rectangular orifices with a major/minor axis ratio of 4:1 and 8:1 and an ovoid orifice having a major/minor axis ratio of 2:1. Three different flow rates were examined (1.68, 3.48 and 6.48 liters/min). Digital measurements of flow velocity at discrete positions along the centerline progressing toward the orifice were analyzed to yield complete flow velocity profiles for each orifice at each flow rate. Results. A clear separation of the flow profiles for the three different flow rates was observed independent of orifice size for all of the circular orifices. The velocity/distance acceleration curves showed highly significant correlations using multiplicative regression fits (y = ax-b, r = 0.94 to 0.99, all p < 0.0001). An equation for quantitatively correlating the a and b coefficients from the multiplicative regression fits with flow rates was derived from stepwise regression analysis: Flow rate = 23a + 3.3b - 1.5 (r = 0.97, p < 0.0001, SEE 0.46 liter/min). Conclusions. In view of the various sizes and shapes encountered clinically for regurgitant orifices, the simplicity of this method for the estimation of the severity of regurgitant lesions might be of importance for clinical applications of this method.
AB - Objectives. In this study we investigated the centerline velocity profile method for flow computation as applied to noncircular, as well as circular, orifices using digital color flow data. Background. Recently it has been suggested that flow volume through an orifice can be estimated more accurately by computing the axial "centerline" flow velocity/distance profile proximal to the orifice. Methods. A total of seven different orifices were mounted in a constant-flow model: four circular orifices, two rectangular orifices with a major/minor axis ratio of 4:1 and 8:1 and an ovoid orifice having a major/minor axis ratio of 2:1. Three different flow rates were examined (1.68, 3.48 and 6.48 liters/min). Digital measurements of flow velocity at discrete positions along the centerline progressing toward the orifice were analyzed to yield complete flow velocity profiles for each orifice at each flow rate. Results. A clear separation of the flow profiles for the three different flow rates was observed independent of orifice size for all of the circular orifices. The velocity/distance acceleration curves showed highly significant correlations using multiplicative regression fits (y = ax-b, r = 0.94 to 0.99, all p < 0.0001). An equation for quantitatively correlating the a and b coefficients from the multiplicative regression fits with flow rates was derived from stepwise regression analysis: Flow rate = 23a + 3.3b - 1.5 (r = 0.97, p < 0.0001, SEE 0.46 liter/min). Conclusions. In view of the various sizes and shapes encountered clinically for regurgitant orifices, the simplicity of this method for the estimation of the severity of regurgitant lesions might be of importance for clinical applications of this method.
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U2 - 10.1016/0735-1097(94)90301-8
DO - 10.1016/0735-1097(94)90301-8
M3 - Article
C2 - 8034881
AN - SCOPUS:0028146359
SN - 0735-1097
VL - 24
SP - 440
EP - 445
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 2
ER -