Estimation of mutation frequencies in normal mammalian cells and the development of cancer

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

A current controversy in cancer research is whether the rate of accumulation of mutations in normal somatic cells is sufficient to account for the number of mutations in malignant cells. This review will focus on the types of mutations that can occur in mammalian somatic cells and the frequency at which some of these mutations have been shown to occur in vivo. Human and mouse mutation detection systems will be highlighted. The possibility that distinct mutational events can arise from a common precursor will be discussed, as will the possibility that inherited and sporadic cancers can acquire mutator phenotypes at different times in tumor development. Consideration will also be given to a potential relationship between an age-related accumulation of mutations and cancer.

Original languageEnglish (US)
Pages (from-to)407-419
Number of pages13
JournalSeminars in Cancer Biology
Volume8
Issue number6
DOIs
StatePublished - Dec 1997

Keywords

  • Aging
  • Cancer
  • Mutant frequencies
  • Mutator phenotype
  • Somatic cell mutations

ASJC Scopus subject areas

  • Cancer Research

Fingerprint Dive into the research topics of 'Estimation of mutation frequencies in normal mammalian cells and the development of cancer'. Together they form a unique fingerprint.

  • Cite this