@article{28d9bc00bbdb475bbc582bab7bb56d17,
title = "Estimating the severity of osteoarthritis with magnetic resonance spectroscopy",
abstract = "This study explores the possibility of estimating the severity of osteoarthritis in the elderly through magnetic resonance measurements of proton relaxation times in articular cartilage. Twenty-five paired samples were cut from eight cartilage specimens. The specimens had been taken in the normal course of knee surgery from patients aged 60 years or older. The reciprocal of the T1 relaxation time ( 1 T1) was found to have a negative association with the histologicalhistochemical Grade of the severity of osteoarthritis. A revised, weighted version of the Mankin-Dorfman severity scale yielded stronger correlations with 1 T1 and with percent water. A nonlinear regression equation expressing osteoarthritis as a function of 1 T1 explained 38% of the variation in the severity of osteoarthritis as measured by the new scale. A superior methodology for estimating the severity of osteoarthritis on the basis of contour maps of the magnetic resonance response is suggested.",
keywords = "Osteoarthritis, magnetic resonance",
author = "Douglas McKeag and Smith, {Blake W.H.} and Ralph Edminster and Thaddeus Laird and Joseph Clark and Scott Herron",
note = "Funding Information: Douglas McKeag, MD, MS: Professor and Coordinator of Sports Medicine, Departmento f Family Practice, College of Human Medicine, Michigan State University; Blake W.H. Smith, PhD: Specialist,D epatimentof Family Practice, College of Human Medicine, Michigan State University; Ralph Edminster, MD: Professor, Departmento f Pathology, College of Human Medicine, Michigan State University; Thaddeus Laird, MD: Fellow in Magnetic Resonance, Department of Radiology, Michigan State University,f ormerly medical student, geriattic fellow, National Council on the Aging/The Travelers, Inc., Washington,D C; Joseph Clark, PhD: Post DoctorateF ellow in Physiology,U niversited e Paris&d, France, formerlyp hysiology student,g raduatea ssistant;S cott Herron, MD: Residenti n Surgery Boston UniversuyH ospital, Boston, MA, formerly medical student,g raduatea ssistant. Supportedb y two researchi nitiation grantsf rom the dean{\textquoteright}s office of the College of Human Medicine and by a Small Research Grant, no. 1 R03 AG05858-01, from the National Instituteo n Aging.",
year = "1992",
month = feb,
doi = "10.1016/0049-0172(92)90053-G",
language = "English (US)",
volume = "21",
pages = "227--238",
journal = "Seminars in Arthritis and Rheumatism",
issn = "0049-0172",
publisher = "W.B. Saunders Ltd",
number = "4",
}