Estimating daily dose for pharmacoepidemiologic studies: Alprazolam as an example

R. E. Johnson, Bentson McFarland, C. A. Corelle, O. T. Woodson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pharmacoepidemiologic research utilizing large automated prescription databases requires measures of daily drug dose. The objectives of this report were to develop a measure of the average daily dose from such a database and to apply it to a specific drug (alprazolam) to determine if the average daily dose had changed over time. An estimate of the average dairy dose was developed by calculating total exposure (in mg) over time and dividing it by the total number of days of exposure over the same time period. The total number of days of exposure was calculated with an algorithm linking prescriptions into periods of use if certain conditions were met. Applying the measure, the average daily dose of alprazolam increased after it was approved for use at higher doses, and we observed no seizure disorders among any users with highest average daily doses. Since the data fields to develop the measure appeared to be valid and are common to most automated prescription systems, and given an assumption that the receipt of multiple dispensings in a consistent temporal sequence indicates that the drug is consumed, average daily doses can be estimated from large automated prescription databases.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalPharmacoepidemiology and Drug Safety
Volume3
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Alprazolam
Prescriptions
Databases
Pharmaceutical Preparations
Epilepsy
Research

Keywords

  • Daily dose
  • Drug utilization
  • Epidemiology
  • Prescription drug

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Estimating daily dose for pharmacoepidemiologic studies : Alprazolam as an example. / Johnson, R. E.; McFarland, Bentson; Corelle, C. A.; Woodson, O. T.

In: Pharmacoepidemiology and Drug Safety, Vol. 3, No. 3, 1994, p. 139-145.

Research output: Contribution to journalArticle

Johnson, R. E. ; McFarland, Bentson ; Corelle, C. A. ; Woodson, O. T. / Estimating daily dose for pharmacoepidemiologic studies : Alprazolam as an example. In: Pharmacoepidemiology and Drug Safety. 1994 ; Vol. 3, No. 3. pp. 139-145.
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