Estimating and comparing cancer progression risks under varying surveillance protocols

Jane M. Lange, Roman Gulati, Amy S. Leonardson, Daniel W. Lin, Lisa F. Newcomb, Bruce J. Trock, H. Ballentine Carter, Peter R. Carroll, Matthew R. Cooperberg, Janet E. Cowan, Lawrence H. Klotz, Ruth Etzioni

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Outcomes after cancer diagnosis and treatment are often observed at discrete times via doctor-patient encounters or specialized diagnostic examinations. Despite their ubiquity as endpoints in cancer studies, such outcomes pose challenges for analysis. In particular, comparisons between studies or patient populations with different surveillance schema may be confounded by differences in visit frequencies. We present a statistical framework based on multistate and hidden Markov models that represents events on a continuous time scale given data with discrete observation times. To demonstrate this framework, we consider the problem of comparing risks of prostate cancer progression across multiple active surveillance cohorts with different surveillance frequencies. We show that the different surveillance schedules partially explain observed differences in the progression risks between cohorts. Our application permits the conclusion that differences in underlying cancer progression risks across cohorts persist after accounting for different surveillance frequencies.

Original languageEnglish (US)
Pages (from-to)1773-1795
Number of pages23
JournalAnnals of Applied Statistics
Volume12
Issue number3
DOIs
StatePublished - Sep 2018

Keywords

  • Active surveillance
  • Hidden Markov model
  • Multistate model
  • Panel data
  • Prostate cancer

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Statistics, Probability and Uncertainty

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  • Cite this

    Lange, J. M., Gulati, R., Leonardson, A. S., Lin, D. W., Newcomb, L. F., Trock, B. J., Carter, H. B., Carroll, P. R., Cooperberg, M. R., Cowan, J. E., Klotz, L. H., & Etzioni, R. (2018). Estimating and comparing cancer progression risks under varying surveillance protocols. Annals of Applied Statistics, 12(3), 1773-1795. https://doi.org/10.1214/17-AOAS1130