Erythropoietin kinetics in normal and uremic sheep

J. Mladenovic, J. W. Eschbach, J. R. Koup, J. F. Garcia, J. W. Adamson

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Homologous erythropoietin (Ep)-rich plasma was infused into sheep to determine the kinetics of this hormone in a large animal model. Ep levels after infusion were measured by radioimmunoassay using a sheep standard. Twenty-seven infusions into normal (14), subtotally nephrectomized (11), and anephric (two) animals were analyzed according to a single-compartment model. The volume of distribution was also calculated, and compared with values obtained indirectly from measurement of chromium 51-labeled red blood cells. The data showed that the t 1/2 of the infused hormone was ~9 hours and was independent of renal function. After multiple infusions, the t 1/2 appeared to shorten. The volume of distribution for this hormone corresponded to the plasma volume of the animals. These studies suggest that Ep, if administered to patients with chronic renal failure, could be given infrequently with little dependence on renal function.

Original languageEnglish (US)
Pages (from-to)659-663
Number of pages5
JournalJournal of Laboratory and Clinical Medicine
Volume105
Issue number6
StatePublished - Dec 1 1985

    Fingerprint

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Mladenovic, J., Eschbach, J. W., Koup, J. R., Garcia, J. F., & Adamson, J. W. (1985). Erythropoietin kinetics in normal and uremic sheep. Journal of Laboratory and Clinical Medicine, 105(6), 659-663.