Epitope recognition and T cell receptors in recurrent autoimmune anterior uveitis in Lewis rats immunized with myelin basic protein

Grazyna Adamus, Maria Manczak, Brad Sugden, Anatol Arendt, Paul A. Hargrave, Halina Offner

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Lewis rats immunized with myelin basic protein (MBP) develop experimental autoimmune encephalomyelitis (EAE) and associated anterior uveitis (AU). Rats recover and become resistant to further reinduction of EAE. We investigated whether the resistance to reinduction of EAE was associated with the resistance to AU in LEW rats reinjected with MBP. We demonstrated that while rats remained resistant to EAE, they become susceptible to uveitis after recovery, and suffered a second episode of disease. The susceptibility to reinduced disease was associated with the recognition of new MBP epitopes. In contrast to the initial episode of AU, TCR Vβ8.2 predominance was not observed in the iris/ciliary body. Our results suggest that T cells specific for MBP, which are rapidly reactivated when re-exposed to antigen, are sufficient to induce clinical uveitis in LEW rats. This process may involve a shifting of T cell specificity from the major encephalitogenic peptide utilizing the Vβ8.2 receptor to a more diverse cell repertoire. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)122-130
Number of pages9
JournalJournal of Neuroimmunology
Volume108
Issue number1-2
DOIs
StatePublished - Aug 1 2000

Fingerprint

Anterior Uveitis
Myelin Basic Protein
T-Cell Antigen Receptor
Autoimmune Experimental Encephalomyelitis
Epitopes
Uveitis
T-Cell Antigen Receptor Specificity
Ciliary Body
Iris
T-Lymphocytes
Antigens
Peptides

Keywords

  • Autoimmunity
  • EAE
  • Peptides/epitopes
  • T cell receptors
  • T lymphocytes
  • Uveitis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Epitope recognition and T cell receptors in recurrent autoimmune anterior uveitis in Lewis rats immunized with myelin basic protein. / Adamus, Grazyna; Manczak, Maria; Sugden, Brad; Arendt, Anatol; Hargrave, Paul A.; Offner, Halina.

In: Journal of Neuroimmunology, Vol. 108, No. 1-2, 01.08.2000, p. 122-130.

Research output: Contribution to journalArticle

@article{1b9034d3380a448bbc4d57221913efbf,
title = "Epitope recognition and T cell receptors in recurrent autoimmune anterior uveitis in Lewis rats immunized with myelin basic protein",
abstract = "Lewis rats immunized with myelin basic protein (MBP) develop experimental autoimmune encephalomyelitis (EAE) and associated anterior uveitis (AU). Rats recover and become resistant to further reinduction of EAE. We investigated whether the resistance to reinduction of EAE was associated with the resistance to AU in LEW rats reinjected with MBP. We demonstrated that while rats remained resistant to EAE, they become susceptible to uveitis after recovery, and suffered a second episode of disease. The susceptibility to reinduced disease was associated with the recognition of new MBP epitopes. In contrast to the initial episode of AU, TCR Vβ8.2 predominance was not observed in the iris/ciliary body. Our results suggest that T cells specific for MBP, which are rapidly reactivated when re-exposed to antigen, are sufficient to induce clinical uveitis in LEW rats. This process may involve a shifting of T cell specificity from the major encephalitogenic peptide utilizing the Vβ8.2 receptor to a more diverse cell repertoire. Copyright (C) 2000 Elsevier Science B.V.",
keywords = "Autoimmunity, EAE, Peptides/epitopes, T cell receptors, T lymphocytes, Uveitis",
author = "Grazyna Adamus and Maria Manczak and Brad Sugden and Anatol Arendt and Hargrave, {Paul A.} and Halina Offner",
year = "2000",
month = "8",
day = "1",
doi = "10.1016/S0165-5728(00)00252-6",
language = "English (US)",
volume = "108",
pages = "122--130",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Epitope recognition and T cell receptors in recurrent autoimmune anterior uveitis in Lewis rats immunized with myelin basic protein

AU - Adamus, Grazyna

AU - Manczak, Maria

AU - Sugden, Brad

AU - Arendt, Anatol

AU - Hargrave, Paul A.

AU - Offner, Halina

PY - 2000/8/1

Y1 - 2000/8/1

N2 - Lewis rats immunized with myelin basic protein (MBP) develop experimental autoimmune encephalomyelitis (EAE) and associated anterior uveitis (AU). Rats recover and become resistant to further reinduction of EAE. We investigated whether the resistance to reinduction of EAE was associated with the resistance to AU in LEW rats reinjected with MBP. We demonstrated that while rats remained resistant to EAE, they become susceptible to uveitis after recovery, and suffered a second episode of disease. The susceptibility to reinduced disease was associated with the recognition of new MBP epitopes. In contrast to the initial episode of AU, TCR Vβ8.2 predominance was not observed in the iris/ciliary body. Our results suggest that T cells specific for MBP, which are rapidly reactivated when re-exposed to antigen, are sufficient to induce clinical uveitis in LEW rats. This process may involve a shifting of T cell specificity from the major encephalitogenic peptide utilizing the Vβ8.2 receptor to a more diverse cell repertoire. Copyright (C) 2000 Elsevier Science B.V.

AB - Lewis rats immunized with myelin basic protein (MBP) develop experimental autoimmune encephalomyelitis (EAE) and associated anterior uveitis (AU). Rats recover and become resistant to further reinduction of EAE. We investigated whether the resistance to reinduction of EAE was associated with the resistance to AU in LEW rats reinjected with MBP. We demonstrated that while rats remained resistant to EAE, they become susceptible to uveitis after recovery, and suffered a second episode of disease. The susceptibility to reinduced disease was associated with the recognition of new MBP epitopes. In contrast to the initial episode of AU, TCR Vβ8.2 predominance was not observed in the iris/ciliary body. Our results suggest that T cells specific for MBP, which are rapidly reactivated when re-exposed to antigen, are sufficient to induce clinical uveitis in LEW rats. This process may involve a shifting of T cell specificity from the major encephalitogenic peptide utilizing the Vβ8.2 receptor to a more diverse cell repertoire. Copyright (C) 2000 Elsevier Science B.V.

KW - Autoimmunity

KW - EAE

KW - Peptides/epitopes

KW - T cell receptors

KW - T lymphocytes

KW - Uveitis

UR - http://www.scopus.com/inward/record.url?scp=0034255748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034255748&partnerID=8YFLogxK

U2 - 10.1016/S0165-5728(00)00252-6

DO - 10.1016/S0165-5728(00)00252-6

M3 - Article

VL - 108

SP - 122

EP - 130

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -