Abstract
Stem cells hold the promise of novel therapy tor treating diseases. Unfortunately, the use and study of embryonic stem cells are currently clouded by ethical controversy. Adult stem cells offer a unique alternative in that they may be isolated, studied, or manipulated without harming the donor. Currently, several obstacles for use of adult stem cells as therapy exist. First, the ability to identify most adult stem cells is impeded by lack of stem cell markers. Second, in vitro systems for manipulating adult stem cell populations are often not well defined. Finally, our understanding of how adult stem cells are regulated within their niche is in its infancy. Next to the hematopoietic stem cell, epithelial stem cells are one of the most widely studied stem cell populations. Even so, the diversity between epithelial functions in different organs makes it difficult to determine whether common themes exist in regulating these related stem cells. Although each epithelial stem cell niche possesses unique features to facilitate its specialized functionality, they likely share many common aspects of regulation. The purpose of this review is to compare how the cell signaling influences the stem cell and its niche in rapidly self-renewing epithelia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 150-165 |
| Number of pages | 16 |
| Journal | Stem Cells |
| Volume | 23 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2005 |
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Keywords
- Adult stem cells
- Epithelial stem cells
- Intestine
- Regulation
- Stem cell niche
ASJC Scopus subject areas
- Cell Biology
Cite this
Epithelial stem cells and their niche : There's no place like home. / Rizvi, Adnan Z.; Wong, Melissa.
In: Stem Cells, Vol. 23, No. 2, 02.2005, p. 150-165.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epithelial stem cells and their niche
T2 - There's no place like home
AU - Rizvi, Adnan Z.
AU - Wong, Melissa
PY - 2005/2
Y1 - 2005/2
N2 - Stem cells hold the promise of novel therapy tor treating diseases. Unfortunately, the use and study of embryonic stem cells are currently clouded by ethical controversy. Adult stem cells offer a unique alternative in that they may be isolated, studied, or manipulated without harming the donor. Currently, several obstacles for use of adult stem cells as therapy exist. First, the ability to identify most adult stem cells is impeded by lack of stem cell markers. Second, in vitro systems for manipulating adult stem cell populations are often not well defined. Finally, our understanding of how adult stem cells are regulated within their niche is in its infancy. Next to the hematopoietic stem cell, epithelial stem cells are one of the most widely studied stem cell populations. Even so, the diversity between epithelial functions in different organs makes it difficult to determine whether common themes exist in regulating these related stem cells. Although each epithelial stem cell niche possesses unique features to facilitate its specialized functionality, they likely share many common aspects of regulation. The purpose of this review is to compare how the cell signaling influences the stem cell and its niche in rapidly self-renewing epithelia.
AB - Stem cells hold the promise of novel therapy tor treating diseases. Unfortunately, the use and study of embryonic stem cells are currently clouded by ethical controversy. Adult stem cells offer a unique alternative in that they may be isolated, studied, or manipulated without harming the donor. Currently, several obstacles for use of adult stem cells as therapy exist. First, the ability to identify most adult stem cells is impeded by lack of stem cell markers. Second, in vitro systems for manipulating adult stem cell populations are often not well defined. Finally, our understanding of how adult stem cells are regulated within their niche is in its infancy. Next to the hematopoietic stem cell, epithelial stem cells are one of the most widely studied stem cell populations. Even so, the diversity between epithelial functions in different organs makes it difficult to determine whether common themes exist in regulating these related stem cells. Although each epithelial stem cell niche possesses unique features to facilitate its specialized functionality, they likely share many common aspects of regulation. The purpose of this review is to compare how the cell signaling influences the stem cell and its niche in rapidly self-renewing epithelia.
KW - Adult stem cells
KW - Epithelial stem cells
KW - Intestine
KW - Regulation
KW - Stem cell niche
UR - http://www.scopus.com/inward/record.url?scp=13744256002&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13744256002&partnerID=8YFLogxK
U2 - 10.1634/stemcells.2004-0096
DO - 10.1634/stemcells.2004-0096
M3 - Article
C2 - 15671140
AN - SCOPUS:13744256002
VL - 23
SP - 150
EP - 165
JO - Stem Cells
JF - Stem Cells
SN - 1066-5099
IS - 2
ER -