Epithelial stem cells and their niche: There's no place like home

Adnan Z. Rizvi, Melissa Wong

    Research output: Contribution to journalArticle

    68 Citations (Scopus)

    Abstract

    Stem cells hold the promise of novel therapy tor treating diseases. Unfortunately, the use and study of embryonic stem cells are currently clouded by ethical controversy. Adult stem cells offer a unique alternative in that they may be isolated, studied, or manipulated without harming the donor. Currently, several obstacles for use of adult stem cells as therapy exist. First, the ability to identify most adult stem cells is impeded by lack of stem cell markers. Second, in vitro systems for manipulating adult stem cell populations are often not well defined. Finally, our understanding of how adult stem cells are regulated within their niche is in its infancy. Next to the hematopoietic stem cell, epithelial stem cells are one of the most widely studied stem cell populations. Even so, the diversity between epithelial functions in different organs makes it difficult to determine whether common themes exist in regulating these related stem cells. Although each epithelial stem cell niche possesses unique features to facilitate its specialized functionality, they likely share many common aspects of regulation. The purpose of this review is to compare how the cell signaling influences the stem cell and its niche in rapidly self-renewing epithelia.

    Original languageEnglish (US)
    Pages (from-to)150-165
    Number of pages16
    JournalStem Cells
    Volume23
    Issue number2
    DOIs
    StatePublished - Feb 2005

    Fingerprint

    Stem Cell Niche
    Adult Stem Cells
    Stem Cells
    Epithelial Cells
    Embryonic Stem Cells
    Cell- and Tissue-Based Therapy
    Hematopoietic Stem Cells
    Population
    Epithelium

    Keywords

    • Adult stem cells
    • Epithelial stem cells
    • Intestine
    • Regulation
    • Stem cell niche

    ASJC Scopus subject areas

    • Cell Biology

    Cite this

    Epithelial stem cells and their niche : There's no place like home. / Rizvi, Adnan Z.; Wong, Melissa.

    In: Stem Cells, Vol. 23, No. 2, 02.2005, p. 150-165.

    Research output: Contribution to journalArticle

    Rizvi, Adnan Z. ; Wong, Melissa. / Epithelial stem cells and their niche : There's no place like home. In: Stem Cells. 2005 ; Vol. 23, No. 2. pp. 150-165.
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