Epithelial carcinogenesis: Dynamic interplay between neoplastic cells and their microenvironment

Léon C.L. Van Kempen, Jin Sae Rhee, Kerstin Dehne, Jake Lee, Dylan R. Edwards, Lisa M. Coussens

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Matrix metalloproteinases (MMPs) have long been thought of as critical factors regulating matrix degradation associated with cell invasion into ectopic tissue compartments during primary tumor growth and metastasis. One member of the MMP family historically linked to these invasive processes is MMP-9/gelatinase B. By studying a transgenic mouse model of de novo epithelial carcinogenesis, new roles for MMP-9 have emerged that broaden the view of its functional contribution to malignant progression. The combined implication of these studies suggest that MMP-9 functionally contributes to cancer development; however, its major regulatory role may be in its ability to activate poorly diffusible and/or matrix-sequestered growth factors that regulate epithelial and/or endothelial cell growth as opposed to regulating cellular invasion across basement membranes.

Original languageEnglish (US)
Pages (from-to)610-623
Number of pages14
JournalDifferentiation
Volume70
Issue number9-10
DOIs
StatePublished - Dec 2002

Keywords

  • Angiogenesis
  • Cancer
  • Inflammation
  • Matrix metalloproteinase
  • Transgenic mice

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology
  • Cancer Research

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