Epistatic quantitative trait loci for alcohol preference in mice

José R. Fernández, Lisa M. Tarantino, Scott Hofer, George P. Vogler, Gerald E. Mcclearn

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Alcohol consumption is a complex trait, responding to the influence of various genes and environmental influences acting in a quantitative fashion. Various studies in alcohol consumption processes have identified quantitative trait locus (QTL) regions across the mouse genome that appear to contribute to this phenotype. The purpose of this study was to examine the influence of interactions between alleles at different loci, a phenomenon known as epistasis, on previously identified QTLs for alcohol consumption in mice. A multiple regression model was developed and applied to test for the significance of the interaction between two QTLs and to quantify this interaction. Our results indicate the presence of epistasis between loci on mouse chromosomes 2 and 3 accounting for 7-8% of the variation in alcohol preference, respectively.

Original languageEnglish (US)
Pages (from-to)431-437
Number of pages7
JournalBehavior Genetics
Volume30
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Quantitative Trait Loci
Alcohol Drinking
alcohol
quantitative trait loci
alcohols
epistasis
Alcohols
mice
loci
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 2
Alleles
Genome
multiple regression
alleles
chromosomes
Phenotype
phenotype
chromosome
allele

Keywords

  • Alcohol consumption
  • Epistasis
  • Gene interaction
  • Mice.
  • QTL

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

Cite this

Fernández, J. R., Tarantino, L. M., Hofer, S., Vogler, G. P., & Mcclearn, G. E. (2000). Epistatic quantitative trait loci for alcohol preference in mice. Behavior Genetics, 30(6), 431-437. https://doi.org/10.1023/A:1010232900342

Epistatic quantitative trait loci for alcohol preference in mice. / Fernández, José R.; Tarantino, Lisa M.; Hofer, Scott; Vogler, George P.; Mcclearn, Gerald E.

In: Behavior Genetics, Vol. 30, No. 6, 2000, p. 431-437.

Research output: Contribution to journalArticle

Fernández, JR, Tarantino, LM, Hofer, S, Vogler, GP & Mcclearn, GE 2000, 'Epistatic quantitative trait loci for alcohol preference in mice', Behavior Genetics, vol. 30, no. 6, pp. 431-437. https://doi.org/10.1023/A:1010232900342
Fernández, José R. ; Tarantino, Lisa M. ; Hofer, Scott ; Vogler, George P. ; Mcclearn, Gerald E. / Epistatic quantitative trait loci for alcohol preference in mice. In: Behavior Genetics. 2000 ; Vol. 30, No. 6. pp. 431-437.
@article{262467dd6cd84a4e9aad3701682ad85a,
title = "Epistatic quantitative trait loci for alcohol preference in mice",
abstract = "Alcohol consumption is a complex trait, responding to the influence of various genes and environmental influences acting in a quantitative fashion. Various studies in alcohol consumption processes have identified quantitative trait locus (QTL) regions across the mouse genome that appear to contribute to this phenotype. The purpose of this study was to examine the influence of interactions between alleles at different loci, a phenomenon known as epistasis, on previously identified QTLs for alcohol consumption in mice. A multiple regression model was developed and applied to test for the significance of the interaction between two QTLs and to quantify this interaction. Our results indicate the presence of epistasis between loci on mouse chromosomes 2 and 3 accounting for 7-8{\%} of the variation in alcohol preference, respectively.",
keywords = "Alcohol consumption, Epistasis, Gene interaction, Mice., QTL",
author = "Fern{\'a}ndez, {Jos{\'e} R.} and Tarantino, {Lisa M.} and Scott Hofer and Vogler, {George P.} and Mcclearn, {Gerald E.}",
year = "2000",
doi = "10.1023/A:1010232900342",
language = "English (US)",
volume = "30",
pages = "431--437",
journal = "Behavior Genetics",
issn = "0001-8244",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Epistatic quantitative trait loci for alcohol preference in mice

AU - Fernández, José R.

AU - Tarantino, Lisa M.

AU - Hofer, Scott

AU - Vogler, George P.

AU - Mcclearn, Gerald E.

PY - 2000

Y1 - 2000

N2 - Alcohol consumption is a complex trait, responding to the influence of various genes and environmental influences acting in a quantitative fashion. Various studies in alcohol consumption processes have identified quantitative trait locus (QTL) regions across the mouse genome that appear to contribute to this phenotype. The purpose of this study was to examine the influence of interactions between alleles at different loci, a phenomenon known as epistasis, on previously identified QTLs for alcohol consumption in mice. A multiple regression model was developed and applied to test for the significance of the interaction between two QTLs and to quantify this interaction. Our results indicate the presence of epistasis between loci on mouse chromosomes 2 and 3 accounting for 7-8% of the variation in alcohol preference, respectively.

AB - Alcohol consumption is a complex trait, responding to the influence of various genes and environmental influences acting in a quantitative fashion. Various studies in alcohol consumption processes have identified quantitative trait locus (QTL) regions across the mouse genome that appear to contribute to this phenotype. The purpose of this study was to examine the influence of interactions between alleles at different loci, a phenomenon known as epistasis, on previously identified QTLs for alcohol consumption in mice. A multiple regression model was developed and applied to test for the significance of the interaction between two QTLs and to quantify this interaction. Our results indicate the presence of epistasis between loci on mouse chromosomes 2 and 3 accounting for 7-8% of the variation in alcohol preference, respectively.

KW - Alcohol consumption

KW - Epistasis

KW - Gene interaction

KW - Mice.

KW - QTL

UR - http://www.scopus.com/inward/record.url?scp=0034434379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034434379&partnerID=8YFLogxK

U2 - 10.1023/A:1010232900342

DO - 10.1023/A:1010232900342

M3 - Article

C2 - 11523702

AN - SCOPUS:0034434379

VL - 30

SP - 431

EP - 437

JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

IS - 6

ER -