Epileptogenic agents applied to trigeminal ganglia: Absence of neuronal hyperexcitability

Kim Burchiel, A. R. Wyler, A. B. Harris

Research output: Contribution to journalArticle

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Abstract

Chronic application of alumina cream to the trigeminal ganglion in 10 cats failed to produce a long-lasting behavioral syndrome of facial dysesthesia. Histologic and electron microscopic analysis demonstrated morphologic similarities between these ganglia and primate neocortical alumina cream epileptic foci. None of 87 ganglia neurons recorded extracellularly exhibited evidence of intrinsic hyperexcitability, i.e., abnormal spontaneous or physiologically evoked activity or any significant differences in threshold of responses to antidromic or orthodromic electrical stimulations, compared to 67 normal ganglion cells. Furthermore, topical application of penicillin to normal ganglia failed to produce abnormal activity in 42 neurons tested. These data suggest that neuronal somata lacking either dendrites or postsynaptic membranes, or both, do not develop abnormal firing behavior when challenged with these two epileptogenic agents.

Original languageEnglish (US)
Pages (from-to)567-579
Number of pages13
JournalEpilepsia
Volume19
Issue number6
Publication statusPublished - 1978
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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