Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers

Rosalie Sears; Joe W. Gray

doi:10.1158/2159-8290.CD-16-1423

Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers

Rosalie Sears, Joe W. Gray

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Invasion and metastasis of a subset of aggressive luminal B breast cancers is driven by the concomitant inactivation of the RasGAPs DAB2IP and RASAL2. Inactivation of both proteins increases RAS activity and drives invasion, whereas inactivation of DAB2IP specifically promotes NF-κB-mediated epithelial-mesenchymal transition.

Original language	English (US)
Pages (from-to)	131-133
Number of pages	3
Journal	Cancer discovery
Volume	7
Issue number	2
DOIs	https://doi.org/10.1158/2159-8290.CD-16-1423
State	Published - Feb 2017

ASJC Scopus subject areas

Oncology

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10.1158/2159-8290.CD-16-1423

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title = "Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers",

abstract = "Invasion and metastasis of a subset of aggressive luminal B breast cancers is driven by the concomitant inactivation of the RasGAPs DAB2IP and RASAL2. Inactivation of both proteins increases RAS activity and drives invasion, whereas inactivation of DAB2IP specifically promotes NF-κB-mediated epithelial-mesenchymal transition.",

author = "Rosalie Sears and Gray, {Joe W.}",

note = "Funding Information: This work was supported by NIH(National Institutes of Health)grants U54 CA112970 (J.W. Gray) and R01 CA196228 (R. Sears). Publisher Copyright: {\textcopyright} 2017 American Association for Cancer Research.",

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AB - Invasion and metastasis of a subset of aggressive luminal B breast cancers is driven by the concomitant inactivation of the RasGAPs DAB2IP and RASAL2. Inactivation of both proteins increases RAS activity and drives invasion, whereas inactivation of DAB2IP specifically promotes NF-κB-mediated epithelial-mesenchymal transition.

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Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers

Abstract

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