Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers

Rosalie Sears; Joe Gray

doi:10.1158/2159-8290.CD-16-1423

Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers

Rosalie Sears, Joe Gray

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

Invasion and metastasis of a subset of aggressive luminal B breast cancers is driven by the concomitant inactivation of the RasGAPs DAB2IP and RASAL2. Inactivation of both proteins increases RAS activity and drives invasion, whereas inactivation of DAB2IP specifically promotes NF-κB-mediated epithelial-mesenchymal transition.

Original language	English (US)
Pages (from-to)	131-133
Number of pages	3
Journal	Cancer Discovery
Volume	7
Issue number	2
DOIs	https://doi.org/10.1158/2159-8290.CD-16-1423
State	Published - Feb 1 2017

Fingerprint

ASJC Scopus subject areas

Oncology

Cite this

Sears, R., & Gray, J. (2017). Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers. Cancer Discovery, 7(2), 131-133. https://doi.org/10.1158/2159-8290.CD-16-1423

@article{712465b0e45f4e1a959a36d27000c972,

title = "Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers",

abstract = "Invasion and metastasis of a subset of aggressive luminal B breast cancers is driven by the concomitant inactivation of the RasGAPs DAB2IP and RASAL2. Inactivation of both proteins increases RAS activity and drives invasion, whereas inactivation of DAB2IP specifically promotes NF-κB-mediated epithelial-mesenchymal transition.",

author = "Rosalie Sears and Joe Gray",

year = "2017",

month = feb

day = "1",

doi = "10.1158/2159-8290.CD-16-1423",

language = "English (US)",

volume = "7",

pages = "131--133",

journal = "Cancer Discovery",

issn = "2159-8274",

publisher = "American Association for Cancer Research Inc.",

number = "2",

}

TY - JOUR

T1 - Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers

AU - Sears, Rosalie

AU - Gray, Joe

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Invasion and metastasis of a subset of aggressive luminal B breast cancers is driven by the concomitant inactivation of the RasGAPs DAB2IP and RASAL2. Inactivation of both proteins increases RAS activity and drives invasion, whereas inactivation of DAB2IP specifically promotes NF-κB-mediated epithelial-mesenchymal transition.

AB - Invasion and metastasis of a subset of aggressive luminal B breast cancers is driven by the concomitant inactivation of the RasGAPs DAB2IP and RASAL2. Inactivation of both proteins increases RAS activity and drives invasion, whereas inactivation of DAB2IP specifically promotes NF-κB-mediated epithelial-mesenchymal transition.

UR - http://www.scopus.com/inward/record.url?scp=85011824732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011824732&partnerID=8YFLogxK

U2 - 10.1158/2159-8290.CD-16-1423

DO - 10.1158/2159-8290.CD-16-1423

M3 - Article

C2 - 28167613

AN - SCOPUS:85011824732

VL - 7

SP - 131

EP - 133

JO - Cancer Discovery

JF - Cancer Discovery

SN - 2159-8274

IS - 2

ER -

Access to Document

10.1158/2159-8290.CD-16-1423