Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers

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Invasion and metastasis of a subset of aggressive luminal B breast cancers is driven by the concomitant inactivation of the RasGAPs DAB2IP and RASAL2. Inactivation of both proteins increases RAS activity and drives invasion, whereas inactivation of DAB2IP specifically promotes NF-κB-mediated epithelial-mesenchymal transition.

Original languageEnglish (US)
Pages (from-to)131-133
Number of pages3
JournalCancer Discovery
Issue number2
StatePublished - Feb 1 2017


ASJC Scopus subject areas

  • Oncology

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