Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers

Rosalie Sears, Joe Gray

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

Invasion and metastasis of a subset of aggressive luminal B breast cancers is driven by the concomitant inactivation of the RasGAPs DAB2IP and RASAL2. Inactivation of both proteins increases RAS activity and drives invasion, whereas inactivation of DAB2IP specifically promotes NF-κB-mediated epithelial-mesenchymal transition.

Original languageEnglish (US)
Pages (from-to)131-133
Number of pages3
JournalCancer Discovery
Volume7
Issue number2
DOIs
StatePublished - Feb 1 2017

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Epithelial-Mesenchymal Transition
Epigenomics
Breast Neoplasms
Neoplasm Metastasis
Proteins

ASJC Scopus subject areas

  • Oncology

Cite this

Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers. / Sears, Rosalie; Gray, Joe.

In: Cancer Discovery, Vol. 7, No. 2, 01.02.2017, p. 131-133.

Research output: Contribution to journal › Article

Sears, R & Gray, J 2017, 'Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers', Cancer Discovery, vol. 7, no. 2, pp. 131-133. https://doi.org/10.1158/2159-8290.CD-16-1423
Sears R, Gray J. Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers. Cancer Discovery. 2017 Feb 1;7(2):131-133. https://doi.org/10.1158/2159-8290.CD-16-1423
Sears, Rosalie ; Gray, Joe. / Epigenomic inactivation of RasGAPs activates RAS signaling in a subset of luminal B breast cancers. In: Cancer Discovery. 2017 ; Vol. 7, No. 2. pp. 131-133.
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